Observational Cohort Study Renal Transplantation University Hospitals Leuven

NCT06505200 | Active Not Recruiting DMC

• 1 other identifier: S64006
• Study Type: observational
• Target: 1,891
• Locations: 1 country
• Sites: 1

Brief Summary

This observational cohort study aims to compile routinely collected clinical, histological and outcome data of kidney transplant recipients, to evaluate risk factors for post-transplant injury, phenotypes of injury, and impact on outcome of such injury, in order to provide clinicians more accurate, less biased and faster tools for diagnosis, clinical management and treatment decisions with regard to kidney transplant rejection.

Conditions

Kidney Transplant Rejection; Kidney Transplantation; Kidney Transplant Failure

Keywords

Clinical Decision Support; Outcome; Risk Markers; Stratification; Histology

Outcome Measures

Primary Outcomes (1)

• Kidney transplant failure

  Graft failure, recipient death

  2004 - 2022

Secondary Outcomes (2)

• Kidney transplant rejection phenotypes

  2004 - 2022

• Kidney transplant function

  2004 - 2022

Interventions

No intervention OTHER

No intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All renal allograft recipients transplanted at the University Hospitals Leuven between 01/03/2004 and 01/06/2022 are included in this study, without restrictions with regard to age, sex, underlying kidney disease etc.

You may qualify if:

• \* All adult kidney transplant recipients transplanted at the University Hospitals Leuven between 01/03/2004 and 01/06/2022, without restrictions with regard to age, sex, underlying kidney disease etc.

You may not qualify if:

• \* Patients with combined transplantations (e.g. heart + kidney, liver + kidney, lung + kidney)

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (1)

University Hospitals Leuven

Leuven, 3000, Belgium

Location

Related Publications (24)

• Cleenders E, Coemans M, Meziyerh S, Callemeyn J, Emonds MP, Gwinner W, Kers J, Kuypers D, Scheffner I, Senev A, Van Loon E, Wellekens K, de Vries APJ, Verbeke G, Naesens M. An observational cohort study examined the change point of kidney function stabilization in the initial period after transplantation. Kidney Int. 2024 Sep;106(3):508-521. doi: 10.1016/j.kint.2024.05.030. Epub 2024 Jun 28.

  PMID: 38945395 BACKGROUND

• Debyser T, Callemeyn J, Coemans M, Kerkhofs J, Koshy P, Kuypers D, Senev A, Tambur AR, Van Loon E, Wellekens K, Naesens M, Emonds MP. Sensitive HLA antibody testing and the risk of antibody-mediated rejection and graft failure. HLA. 2024 Jun;103(6):e15586. doi: 10.1111/tan.15586.

  PMID: 38932739 BACKGROUND

• Yoo D, Divard G, Raynaud M, Cohen A, Mone TD, Rosenthal JT, Bentall AJ, Stegall MD, Naesens M, Zhang H, Wang C, Gueguen J, Kamar N, Bouquegneau A, Batal I, Coley SM, Gill JS, Oppenheimer F, De Sousa-Amorim E, Kuypers DRJ, Durrbach A, Seron D, Rabant M, Van Huyen JD, Campbell P, Shojai S, Mengel M, Bestard O, Basic-Jukic N, Juric I, Boor P, Cornell LD, Alexander MP, Toby Coates P, Legendre C, Reese PP, Lefaucheur C, Aubert O, Loupy A. A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients. Nat Commun. 2024 Jan 16;15(1):554. doi: 10.1038/s41467-023-44595-z.

  PMID: 38228634 BACKGROUND

• Yi Z, Xi C, Menon MC, Cravedi P, Tedla F, Soto A, Sun Z, Liu K, Zhang J, Wei C, Chen M, Wang W, Veremis B, Garcia-Barros M, Kumar A, Haakinson D, Brody R, Azeloglu EU, Gallon L, O'Connell P, Naesens M, Shapiro R, Colvin RB, Ward S, Salem F, Zhang W. A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization. Kidney Int. 2024 Feb;105(2):281-292. doi: 10.1016/j.kint.2023.09.031. Epub 2023 Nov 3.

  PMID: 37923131 BACKGROUND

• Cleenders E, Koshy P, Van Loon E, Lagrou K, Beuselinck K, Andrei G, Crespo M, De Vusser K, Kuypers D, Lerut E, Mertens K, Mineeva-Sangwo O, Randhawa P, Senev A, Snoeck R, Sprangers B, Tinel C, Van Craenenbroeck A, van den Brand J, Van Ranst M, Verbeke G, Coemans M, Naesens M. An observational cohort study of histological screening for BK polyomavirus nephropathy following viral replication in plasma. Kidney Int. 2023 Nov;104(5):1018-1034. doi: 10.1016/j.kint.2023.07.025. Epub 2023 Aug 19.

  PMID: 37598855 BACKGROUND

• Truchot A, Raynaud M, Kamar N, Naesens M, Legendre C, Delahousse M, Thaunat O, Buchler M, Crespo M, Linhares K, Orandi BJ, Akalin E, Pujol GS, Silva HT Jr, Gupta G, Segev DL, Jouven X, Bentall AJ, Stegall MD, Lefaucheur C, Aubert O, Loupy A. Machine learning does not outperform traditional statistical modelling for kidney allograft failure prediction. Kidney Int. 2023 May;103(5):936-948. doi: 10.1016/j.kint.2022.12.011. Epub 2022 Dec 23.

  PMID: 36572246 BACKGROUND

• Vaulet T, Divard G, Thaunat O, Koshy P, Lerut E, Senev A, Aubert O, Van Loon E, Callemeyn J, Emonds MP, Van Craenenbroeck A, De Vusser K, Sprangers B, Rabeyrin M, Dubois V, Kuypers D, De Vos M, Loupy A, De Moor B, Naesens M. Data-Driven Chronic Allograft Phenotypes: A Novel and Validated Complement for Histologic Assessment of Kidney Transplant Biopsies. J Am Soc Nephrol. 2022 Nov;33(11):2026-2039. doi: 10.1681/ASN.2022030290. Epub 2022 Sep 7.

  PMID: 36316096 BACKGROUND

• Coemans M, Verbeke G, Dohler B, Susal C, Naesens M. Bias by censoring for competing events in survival analysis. BMJ. 2022 Sep 13;378:e071349. doi: 10.1136/bmj-2022-071349. No abstract available.

  PMID: 36100269 BACKGROUND

• Senev A, Van Loon E, Lerut E, Coemans M, Callemeyn J, Daniels L, Kerkhofs J, Koshy P, Kuypers D, Lamarthee B, Sprangers B, Tinel C, Van Craenenbroeck AH, Van Sandt V, Emonds MP, Naesens M. Association of Predicted HLA T-Cell Epitope Targets and T-Cell-Mediated Rejection After Kidney Transplantation. Am J Kidney Dis. 2022 Dec;80(6):718-729.e1. doi: 10.1053/j.ajkd.2022.04.009. Epub 2022 Jun 9.

  PMID: 35690154 BACKGROUND

• Senev A, Lerut E, Coemans M, Callemeyn J, Copley HC, Claas F, Koshy P, Kosmoliaptsis V, Kuypers D, Sprangers B, Van Craenenbroeck A, Van Loon E, Van Sandt V, Emonds MP, Naesens M. Association of HLA Mismatches and Histology Suggestive of Antibody-Mediated Injury in the Absence of Donor-Specific Anti-HLA Antibodies. Clin J Am Soc Nephrol. 2022 Aug;17(8):1204-1215. doi: 10.2215/CJN.00570122. Epub 2022 Jun 1.

  PMID: 35649719 BACKGROUND

• Van Loon E, Zhang W, Coemans M, De Vos M, Emonds MP, Scheffner I, Gwinner W, Kuypers D, Senev A, Tinel C, Van Craenenbroeck AH, De Moor B, Naesens M. Forecasting of Patient-Specific Kidney Transplant Function With a Sequence-to-Sequence Deep Learning Model. JAMA Netw Open. 2021 Dec 1;4(12):e2141617. doi: 10.1001/jamanetworkopen.2021.41617.

  PMID: 34967877 BACKGROUND

• Kers J, Bulow RD, Klinkhammer BM, Breimer GE, Fontana F, Abiola AA, Hofstraat R, Corthals GL, Peters-Sengers H, Djudjaj S, von Stillfried S, Holscher DL, Pieters TT, van Zuilen AD, Bemelman FJ, Nurmohamed AS, Naesens M, Roelofs JJTH, Florquin S, Floege J, Nguyen TQ, Kather JN, Boor P. Deep learning-based classification of kidney transplant pathology: a retrospective, multicentre, proof-of-concept study. Lancet Digit Health. 2022 Jan;4(1):e18-e26. doi: 10.1016/S2589-7500(21)00211-9. Epub 2021 Nov 15.

  PMID: 34794930 BACKGROUND

• Callemeyn J, Senev A, Coemans M, Lerut E, Sprangers B, Kuypers D, Koenig A, Thaunat O, Emonds MP, Naesens M. Missing Self-Induced Microvascular Rejection of Kidney Allografts: A Population-Based Study. J Am Soc Nephrol. 2021 Aug;32(8):2070-2082. doi: 10.1681/ASN.2020111558. Epub 2021 Jul 22.

  PMID: 34301794 BACKGROUND

• Coemans M, Senev A, Van Loon E, Lerut E, Sprangers B, Kuypers D, Emonds MP, Verbeke G, Naesens M. The evolution of histological changes suggestive of antibody-mediated injury, in the presence and absence of donor-specific anti-HLA antibodies. Transpl Int. 2021 Oct;34(10):1824-1836. doi: 10.1111/tri.13964. Epub 2021 Sep 12.

  PMID: 34197662 BACKGROUND

• Senev A, Emonds MP, Naesens M. Second field high-resolution HLA typing for immunologic risk stratification in kidney transplantation. Am J Transplant. 2021 Oct;21(10):3502-3503. doi: 10.1111/ajt.16606. Epub 2021 Apr 30. No abstract available.

  PMID: 33866671 BACKGROUND

• Vaulet T, Divard G, Thaunat O, Lerut E, Senev A, Aubert O, Van Loon E, Callemeyn J, Emonds MP, Van Craenenbroeck A, De Vusser K, Sprangers B, Rabeyrin M, Dubois V, Kuypers D, De Vos M, Loupy A, De Moor B, Naesens M. Data-driven Derivation and Validation of Novel Phenotypes for Acute Kidney Transplant Rejection using Semi-supervised Clustering. J Am Soc Nephrol. 2021 May 3;32(5):1084-1096. doi: 10.1681/ASN.2020101418. Epub 2021 Mar 9.

  PMID: 33687976 BACKGROUND

• Senev A, Van Loon E, Lerut E, Callemeyn J, Coemans M, Van Sandt V, Kuypers D, Emonds MP, Naesens M. Risk factors, histopathological features, and graft outcome of transplant glomerulopathy in the absence of donor-specific HLA antibodies. Kidney Int. 2021 Aug;100(2):401-414. doi: 10.1016/j.kint.2021.01.029. Epub 2021 Mar 3.

  PMID: 33675843 BACKGROUND

• Reese PP, Aubert O, Naesens M, Huang E, Potluri V, Kuypers D, Bouquegneau A, Divard G, Raynaud M, Bouatou Y, Vo A, Glotz D, Legendre C, Lefaucheur C, Jordan S, Empana JP, Jouven X, Loupy A. Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the United States: A Comparison of International Transplant Practices and Outcomes. J Am Soc Nephrol. 2021 Feb;32(2):397-409. doi: 10.1681/ASN.2020040464. Epub 2020 Dec 15.

  PMID: 33323474 BACKGROUND

• Koenig A, Mezaache S, Callemeyn J, Barba T, Mathias V, Sicard A, Charreau B, Rabeyrin M, Dijoud F, Picard C, Meas-Yedid V, Olivo-Marin JC, Morelon E, Naesens M, Dubois V, Thaunat O. Missing Self-Induced Activation of NK Cells Combines with Non-Complement-Fixing Donor-Specific Antibodies to Accelerate Kidney Transplant Loss in Chronic Antibody-Mediated Rejection. J Am Soc Nephrol. 2021 Feb;32(2):479-494. doi: 10.1681/ASN.2020040433. Epub 2020 Nov 25.

  PMID: 33239394 BACKGROUND

• Raynaud M, Aubert O, Reese PP, Bouatou Y, Naesens M, Kamar N, Bailly E, Giral M, Ladriere M, Le Quintrec M, Delahousse M, Juric I, Basic-Jukic N, Gupta G, Akalin E, Yoo D, Chin CS, Proust-Lima C, Bohmig G, Oberbauer R, Stegall MD, Bentall AJ, Jordan SC, Huang E, Glotz D, Legendre C, Montgomery RA, Segev DL, Empana JP, Grams ME, Coresh J, Jouven X, Lefaucheur C, Loupy A. Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation. Kidney Int. 2021 Jan;99(1):186-197. doi: 10.1016/j.kint.2020.07.025. Epub 2020 Aug 8.

  PMID: 32781106 BACKGROUND

• Van Loon E, Lerut E, Senev A, Coemans M, Pirenne J, Monbaliu D, Jochmans I, Sainz Barriga M, De Vusser K, Van Craenenbroeck AH, Sprangers B, Emonds MP, Kuypers D, Naesens M. The Histological Picture of Indication Biopsies in the First 2 Weeks after Kidney Transplantation. Clin J Am Soc Nephrol. 2020 Oct 7;15(10):1484-1493. doi: 10.2215/CJN.04230320. Epub 2020 Aug 10.

  PMID: 32778537 BACKGROUND

• Senev A, Coemans M, Lerut E, Van Sandt V, Kerkhofs J, Daniels L, Driessche MV, Compernolle V, Sprangers B, Van Loon E, Callemeyn J, Claas F, Tambur AR, Verbeke G, Kuypers D, Emonds MP, Naesens M. Eplet Mismatch Load and De Novo Occurrence of Donor-Specific Anti-HLA Antibodies, Rejection, and Graft Failure after Kidney Transplantation: An Observational Cohort Study. J Am Soc Nephrol. 2020 Sep;31(9):2193-2204. doi: 10.1681/ASN.2020010019. Epub 2020 Aug 6.

  PMID: 32764139 BACKGROUND

• Senev A, Emonds MP, Van Sandt V, Lerut E, Coemans M, Sprangers B, Kuypers D, Naesens M. Clinical importance of extended second field high-resolution HLA genotyping for kidney transplantation. Am J Transplant. 2020 Dec;20(12):3367-3378. doi: 10.1111/ajt.15938. Epub 2020 May 15.

  PMID: 32337773 BACKGROUND

• Van Loon E, Senev A, Lerut E, Coemans M, Callemeyn J, Van Keer JM, Daniels L, Kuypers D, Sprangers B, Emonds MP, Naesens M. Assessing the Complex Causes of Kidney Allograft Loss. Transplantation. 2020 Dec;104(12):2557-2566. doi: 10.1097/TP.0000000000003192.

  PMID: 32091487 BACKGROUND

Study Officials

• Maarten Naesens, MD PhD

  Universitaire Ziekenhuizen KU Leuven

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 10, 2024
• First Posted: July 17, 2024
• Study Start: March 1, 2004
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: May 6, 2026

Record last verified: 2026-04

Locations

BE (1)