Intraocular Pressure in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass

NCT06494969 | Completed

• 1 other identifier: Yasemin1
• Study Type: observational
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study to compare the effects of sevoflurane-based anesthesia and propofol-based total intravenous anesthesia on intraocular pressure (IOP) during coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass (CPB). The primary endpoint was to examine the effects of propofol-based total intravenous anesthesia (TIVA) and sevoflurane-based anesthesia methods on IOP during CABG operation. Secondary endpoints included a comparison of hemodynamic variables, blood gas values, intensive care, and hospital stay.

Conditions

Intraocular Pressure; Anesthesia

Keywords

Intraocular pressure; cardiac surgery; coronary artery bypass grafting

Outcome Measures

Primary Outcomes (1)

• Intraocular pressure during coronary artery bypass graft surgery with cardiopulmonary bypass

  Examine the effects of propofol based total intravenous anesthesia and sevoflurane-based anesthesia methods on intraocular pressure during coronary artery bypass graft surgery operation

  Through study completion, an average of 6 months

Study Arms (2)

Group P

Propofol-based total intravenous anesthesia

Device: Intraocular pressure measurement

Group S

Sevoflurane-based anesthesia

Device: Intraocular pressure measurement

Interventions

Intraocular pressure measurement DEVICE

Intraocular pressures were measured and recorded at 8 predefined time points using a tonometer; before anesthesia induction (T1), 10 min after induction (T2), immediately before the beginning of CPB (T3), 3 minute after the beginning of CPB (T4), 3 minute after cross-clamping (T5), 3min after cross-clamp removal (T6), immediately before the weaning of CPB (T7), and end of the surgery (immediately after skin closure) (T8).

Group P; Group S

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing elective coronary artery bypass grafting surgery with cardiopulmonary bypass (CPB) were included.

You may qualify if:

• Patients undergoing elective coronary artery bypass grafting surgery with cardiopulmonary bypass (CPB)

You may not qualify if:

• history of cardiac surgery
• diabetic retinopathy
• cataract
• uncontrolled hypertension
• chronic kidney disease
• glaucoma
• previous eye surgery
• previous neurological disease
• allergy to propofol or sevoflurane
• baseline intraocular pressure (IOP) greater than 30 mmHg

Sponsors & Collaborators

• Antalya Training and Research Hospital: lead

Study Sites (1)

Health Science University, Antalya Training and Research Hospital

Antalya, Muratpasa, 071**, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Tonometry, Ocular

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Ophthalmological; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Ali Sait Kavaklı

  Associate professor

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 28, 2024
• First Posted: July 10, 2024
• Study Start: September 1, 2021
• Primary Completion: January 3, 2022
• Study Completion: January 28, 2022
• Last Updated: July 10, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)