" Role of Diffusion Weighted Image in the Diagnosis and Follow up of Breast Cancer"

NCT06494865 | Not Yet Recruiting

• 1 other identifier: soh-Med-24-06-23MS
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

Breast MRI has become an important tool for breast cancer detection and characterization.Contrast enhanced MRI(CE-MRI) is currently the most sensitive detection technique for diagnosis of breast cancer.

Conditions

Breast Cancer

Outcome Measures

Primary Outcomes (1)

• Rate of correlated false positive results of MRI DWI for the lesion with the positive results by histopathology.

  evaluation of the lesion with MRI DWI and histopathology for detect rate of false posive results

  6 months

Interventions

MRI device DEVICE

Standered breast coils with small field of veiw and thin sections will be used for the examinatio. MRI breast including Axial T1WI, T2WI Stir contrast DWI and Stir sagittal T1WI with contrast traction and subtraction

Eligibility Criteria

• Age: 18 Years - 70 Years
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Female gender * Age more than 18 years * Patients presented with breast lump * Pateints with recurrent breast cancer following chemotherapy or radiotherapy sessions.

You may qualify if:

• \* Female gender
• Age more than 18 years
• Patients presented with breast lump
• Patients with recurrent breast cancer following chemotherapy or radiotherapy sessions.

You may not qualify if:

• Male gender
• Age younger than 18 years
• Patients with recent breast trauma in the same diseased breast within the last 6 months
• Lactating female presented with acute symptoms as trauma or breast abscess
• Contraindication to perform MRI examination .these include : Cardiac pacemaker -Metallic aneurysm clips

Sponsors & Collaborators

• Sohag University: lead

Related Publications (4)

• Stachs A, Stubert J, Reimer T, Hartmann S. Benign Breast Disease in Women. Dtsch Arztebl Int. 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565.

  PMID: 31554551 BACKGROUND

• Butti R, Das S, Gunasekaran VP, Yadav AS, Kumar D, Kundu GC. Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges. Mol Cancer. 2018 Feb 19;17(1):34. doi: 10.1186/s12943-018-0797-x.

  PMID: 29455658 BACKGROUND

• Shi RY, Yao QY, Wu LM, Xu JR. Breast Lesions: Diagnosis Using Diffusion Weighted Imaging at 1.5T and 3.0T-Systematic Review and Meta-analysis. Clin Breast Cancer. 2018 Jun;18(3):e305-e320. doi: 10.1016/j.clbc.2017.06.011. Epub 2017 Jul 5.

  PMID: 28802529 BACKGROUND

• Yilmaz E, Sari O, Yilmaz A, Ucar N, Aslan A, Inan I, Parlakkilic UT. Diffusion-Weighted Imaging for the Discrimination of Benign and Malignant Breast Masses; Utility of ADC and Relative ADC. J Belg Soc Radiol. 2018 Feb 7;102(1):24. doi: 10.5334/jbsr.1258.

  PMID: 30039037 BACKGROUND

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Central Study Contacts

Mennatullah A Ibrahim, resident

CONTACT

01015003865; menaashraf@med.sohag.edu.eg

Medhat I Mohammed, professor

CONTACT

01014005636

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident-radiology department-sohag hospital university

Study Record Dates

• First Submitted: July 2, 2024
• First Posted: July 10, 2024
• Study Start: August 1, 2024
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: August 7, 2024

Record last verified: 2024-08