Dosimetric Comparison of Three Radiation Techniques for Hypofractionated Whole Breast Radiotherapy in Early Breast Cancer
1 other identifier
observational
30
0 countries
N/A
Brief Summary
We aim to compare three different radiation delivery techniques, namely three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiotherapy (IMRT) and volumetric modulated radiation therapy (VMAT) in left-sided early breast cancer patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jul 2022
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 24, 2022
CompletedFirst Posted
Study publicly available on registry
May 27, 2022
CompletedStudy Start
First participant enrolled
July 20, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2025
CompletedMay 27, 2022
May 1, 2022
2 years
May 24, 2022
May 24, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Comparison of coverage of planned target volume(PTV) among the three plans.
PTV coverage in dose is compared among the three plans.
1 year
Comparison of doses to organs at risk among the three plans.
mean dose of the heart, lung volume receiving 20Gy, esophageal doses will be compared among the three plans
1 year
Secondary Outcomes (1)
Comparison of target homogeneity among the three plans.
1 year
Study Arms (3)
3DCRT group
In this plan, we will create plans using three dimensional conformal radiotherapy, evaluate organs at risk doses, dose homogeneity and planned target volume coverage. Then compare these parameters with the two other plans.
IMRT group
In this plan, we will create plans using intensity modulated radiotherapy (IMRT), evaluate organs at risk doses, dose homogeneity and planned target volume coverage. Then compare these parameters with the two other plans.
VMAT plan
In this plan, we will create plans using volumetric modulated radiotherapy (VMAT), evaluate organs at risk doses, dose homogeneity and planned target volume coverage. Then compare these parameters with the two other plans.
Eligibility Criteria
30 Female patients who will present to clinical Oncology department with early breast cancer, with pathological staging ≤ T2N0M0 and are operated by conservative breast surgery will be included in our current study.
You may qualify if:
- left sided early breast cancer patients. Should have histopathological prove to have invasive breast cancer. Operated by breast conservative surgery. Have no associated comorbidities
You may not qualify if:
- locally advanced breast cancer. Patients who have total mastectomy. Patients who had previous chest irradiation or known comorbidities.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Sohag Universitylead
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Alshaymaa Abdelghaffar, PhD
Sohag University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Lecturer of Clinical Oncology
Study Record Dates
First Submitted
May 24, 2022
First Posted
May 27, 2022
Study Start
July 20, 2022
Primary Completion
July 1, 2024
Study Completion
August 1, 2025
Last Updated
May 27, 2022
Record last verified: 2022-05