Online Interplay Between Deciding and Acting With Mild Cognitive Impairment

NCT06493422 | Completed

• 2 other identifiers: 2026374-5U54GM104941
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators aim to understand the interplay and neural structures involved with decision--making and movement for participants with mild cognitive impairment. Rapidly deciding and acting becomes bottlenecked with mild cognitive impairment and Alzheimer's, leading to detrimental outcomes such as falling and car crashes. The investigators work will have a tangible impact by discovering sensitive biomarkers to detect disease onset and pave the way for informed and effective neurorehabilitation.

Conditions

Mild Cognitive Impairment

Keywords

Reaching; Brain; Decisions

Outcome Measures

Primary Outcomes (2)

• Reaching Movements

  Hand position will be recorded throughout each trial during the behavioral task

  through study completion, an average of 1 year

• Change in brain mechanical properties

  Investigators are assessing change in brain structure through mechanical properties

  through study completion, an average of 1 year

Secondary Outcomes (1)

• Decision Time

  through study completion, an average of 1 year

Study Arms (2)

Reaching task

EXPERIMENTAL

Mild cognitive impairment participants will make decisions while moving

Behavioral: Reaching Movements

Reaching Task

ACTIVE COMPARATOR

Age-match control participants will make decision while moving

Behavioral: Reaching Movements

Interventions

Reaching Movements BEHAVIORAL

participants will perform a perceptual decision making task while moving their hand.

Reaching Task; Reaching task

Eligibility Criteria

• Age: 45 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• age 45 - 90 years
• Perfect or corrected vision
• Ability to reach
• Neurotypical Age-Matched control participants - No history of neurological disorders or injury.
• Mild Cognitive Impairment participants - clinical diagnosis of amnestic mild cognitive impairment.

You may not qualify if:

• Any injury or condition that impacts reaching
• Traumatic brain injury, such as concussion, in the last 6 months.
• Neurotypical Age-Matched control participants: Modified Telephone Interview for Cognitive Status (TICS-m) score \< 34
• Mild Cognitive Impairment participants: Modified Telephone Interview for Cognitive Status (TICS-m) score \> 34
• Mild Cognitive Impairment participants: Mini-Mental State Examination Second Edition (MMSE-2) score \< 21.

Sponsors & Collaborators

• University of Delaware: lead
• National Institutes of Health (NIH): collaborator
• National Institute of General Medical Sciences (NIGMS): collaborator

Study Sites (1)

University of Delaware

Newark, Delaware, 19713, United States

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Josh Cashaback

  University of Delaware

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 18, 2024
• First Posted: July 10, 2024
• Study Start: January 28, 2025
• Primary Completion: June 30, 2026
• Study Completion: June 30, 2026
• Last Updated: July 6, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)