Correlation Between Optic Nerve Sheath Diameter and Neurological Deficit in Adult Patients With Suspected Ischemic Stroke

NCT06492681 | Completed

• 1 other identifier: 00001
• Study Type: observational
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The ultrasound of the optic nerve sheath diameter (ONSD) is a non-invasive tool used in the detection of intracranial hypertension and other neurological conditions. The aim of this research is to evaluate the correlation between the ultrasound measurement of the optic nerve sheath diameter and the side of neurological focus in the physical examination of adult patients evaluated in emergency departments.

Conditions

Ischemic Stroke

Keywords

optic nerve sheath diameter; stroke; emergency department

Outcome Measures

Primary Outcomes (1)

• Correlation between optic nerve sheath and side of clinical neurological focalization

  Estimate the correlation between the ultrasound measurement of the optic nerve sheath diameter and the side of neurological focus in the physical examination of adult patients evaluated in emergency departments.

  In the first 4 hours of arrival to Emergency Department

Secondary Outcomes (1)

• sensitivity and specificity of the ultrasound measurement of the optic nerve sheath diameter for predicting the side of neurological focus.

  In the first 4 hours of arrival to Emergency Department

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study aims to include a diverse adult population, encompassing various ages, genders, and ethnic backgrounds, reflective of the general demographic seen in emergency departments with suspected ischemic stroke. By doing so, the study seeks to enhance the generalizability of its findings across different subgroups within the adult population.

You may qualify if:

• Patients with suspected acute ischemic stroke
• CT scan negative to hemorrhagic stroke
• Informed consent

You may not qualify if:

• Contraindications to perform ocular ultrasound
• Patients with ocular surgery

Sponsors & Collaborators

• Clinica Mexico: lead

Study Sites (1)

Clinica Mexico

Piedras Negras, Coahuila, 26020, Mexico

Location

Related Publications (5)

• Lau T, Ahn JS, Manji R, Kim DJ. A Narrative Review of Point of Care Ultrasound Assessment of the Optic Nerve in Emergency Medicine. Life (Basel). 2023 Feb 15;13(2):531. doi: 10.3390/life13020531.

  PMID: 36836888 BACKGROUND

• Nathani A, Ghamande SA, Kambhampati S, Anderson B, Lohse M, White HD. The Use of POCUS-Obtained Optic Nerve Sheath Diameter in Intracerebral Hemorrhage. POCUS J. 2023 Nov 27;8(2):170-174. doi: 10.24908/pocus.v8i2.16563. eCollection 2023.

  PMID: 38099170 BACKGROUND

• Rajajee V, Vanaman M, Fletcher JJ, Jacobs TL. Optic nerve ultrasound for the detection of raised intracranial pressure. Neurocrit Care. 2011 Dec;15(3):506-15. doi: 10.1007/s12028-011-9606-8.

  PMID: 21769456 BACKGROUND

• Bauerle J, Lochner P, Kaps M, Nedelmann M. Intra- and interobsever reliability of sonographic assessment of the optic nerve sheath diameter in healthy adults. J Neuroimaging. 2012 Jan;22(1):42-5. doi: 10.1111/j.1552-6569.2010.00546.x. Epub 2010 Dec 1.

  PMID: 21121998 BACKGROUND

• Kimberly HH, Shah S, Marill K, Noble V. Correlation of optic nerve sheath diameter with direct measurement of intracranial pressure. Acad Emerg Med. 2008 Feb;15(2):201-4. doi: 10.1111/j.1553-2712.2007.00031.x.

  PMID: 18275454 BACKGROUND

MeSH Terms

Conditions

Ischemic Stroke; Stroke; Emergencies

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Research and Critical Care Medicine

Study Record Dates

• First Submitted: July 1, 2024
• First Posted: July 9, 2024
• Study Start: September 1, 2024
• Primary Completion: August 30, 2025
• Study Completion: September 1, 2025
• Last Updated: September 16, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

ME (1)