Liver Function Abnormalities in Patients With Acute Heart Failure

NCT06491628 | Not Yet Recruiting

• 1 other identifier: LFTs abnormalities in AHF
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate liver function test abnormalities and to identify associated cardiac and non cardiac factors mediating hepatic impairment in acute heart failure patients

Conditions

Acute Heart Failure

Keywords

LFTs, AHF

Outcome Measures

Primary Outcomes (1)

• Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals

  assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF

  baseline

Secondary Outcomes (1)

• Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals

  1 year

Study Arms (5)

Acute decompensated heart failure (de novo or as decompensation of chronic heart failure)

This umbrella term includes patients presenting forthe first time with typical symptoms and signs of heart failure(de novo AHF) and also those with worsening of their pre-existing cardiomyopathy (acute decompensated heart failure).

Behavioral: Avoiding the risk factors

Pulmonary edema

It's the real clinical presentation of AHF, typically, signs and symptoms develope rapidly and patients demonstrate severe respiratory distress with tachypnea, orthopnea and pulmonary congestion

Behavioral: Avoiding the risk factors

Hypertensive acute heart failure

the condition is associated with elevated blood pressure with accompanying dyspnea. orthopnea and pulmonary congestion, often in patients with relatively preserved left ventricle ejection fraction

Behavioral: Avoiding the risk factors

cardiogenic shock

severe peripheral hypoperfusion wih subsequent end organs damage,typically it's associated with low blood pressure and low urine output

Behavioral: Avoiding the risk factors

Acute coronary syndrome complicated by heart failure

characterized by complex structural, hemodynamic and neurohormonal interaction need urgent referral for coronary intervention poor outcome

Behavioral: Avoiding the risk factors

Interventions

Avoiding the risk factors BEHAVIORAL

Exercise, Salt and lipid reduction in diet, smoking cessation

Acute coronary syndrome complicated by heart failure; Acute decompensated heart failure (de novo or as decompensation of chronic heart failure); Hypertensive acute heart failure; Pulmonary edema; cardiogenic shock

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients aged 18 yrs or older presenting with AHF

You may qualify if:

• patients aged 18 yrs or older presenting with AHF

You may not qualify if:

• Congenital heart disease
• acute and chronic liver diseases

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university

Sohag, Egypt

Location

MeSH Terms

Conditions

Hemophilia A

Condition Hierarchy (Ancestors)

Blood Coagulation Disorders, Inherited; Blood Coagulation Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Coagulation Protein Disorders; Hemorrhagic Disorders; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Hamdy Saad

  Sohag University

  STUDY CHAIR

• Haitham Mohammad

  Sohag University

  STUDY CHAIR

Central Study Contacts

Sara Mohamed

CONTACT

+201117517685; Sara_mohamed_post@med.Sohag.edu.eg

Hassan Ahmed

CONTACT

+201003459741

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals

Study Record Dates

• First Submitted: July 1, 2024
• First Posted: July 9, 2024
• Study Start: July 1, 2024
• Primary Completion: July 1, 2025
• Study Completion: August 1, 2025
• Last Updated: July 10, 2024

Record last verified: 2024-07

Locations

EG (1)