NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome

NCT06490926 | Recruiting

• 1 other identifier: 2023KJT075
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

At present, the diagnosis of Parkinsons disease(PD) mainly relies on clinical symptoms and is easily confused with atypical Parkinsonian syndrome(APS) in the early stages. There is an urgent need for reliable biomarkers. This project aims to use metabolomics technology based on proton nuclear magnetic resonance spectroscopy to study the metabolomic characteristics of patients with PD and APS, and preliminarily screen for possible diagnostic biomarkers of PD and APS.

Conditions

Progressive Supranuclear Palsy; Multiple System Atrophy; Parkinson's Disease

Keywords

Progressive Supranuclear Palsy; Multiple System Atrophy; Parkinson Disease; nuclear magnetic resonance

Outcome Measures

Primary Outcomes (1)

• metabolite

  baseline

Study Arms (4)

Parkinson's disease

Age range from 45 to 80 years old; ② Patients with idiopathic Parkinson's disease who meet the diagnostic criteria of the International Committee on Motor Disorders (MDS) for Parkinson's disease (2015); ③ Classification criteria for subtypes of Parkinson's disease: Tremor predominant type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≥ 1.15 PIGD type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≤ 0.9

progressive supranuclear palsy

PSP inclusion criteria ① Age range from 45 to 80 years old; ② PSP patients who meet the diagnostic criteria for progressive supranuclear palsy in China (2016) or the diagnostic criteria for progressive supranuclear palsy in the International Society for Parkinson's Disease and Movement Disorders (MDS) (2017)

healthy control

Volunteers aged 45-80 who are matched for age, gender, and underlying diseases, have no neurological disorders, and have not Take any medication.

multiple system atrophy

MSA inclusion criteria * Age range from 45 to 80 years old; ② Meets the Chinese expert consensus on the diagnostic criteria for multiple system atrophy (2017) or the International Society for Parkinson's Disease and Movement Disorders (MDS) diagnostic criteria for multiple system atrophy (2022) ③ MSA subtype grouping: MSA is divided into MSA-P and MSA-C subtypes based on the severity of initial and/or motor symptoms, with Patients with Parkinson's syndrome as the main type are MSA-P, while patients with cerebellar syndrome as the main type are MSA-C.

Eligibility Criteria

• Age: 45 Years - 80 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

from Fujian Medical University Union Hospital

You may qualify if:

• Age range from 45 to 80 years old;
• Age range from 45 to 80 years old;
• Meets the Chinese expert consensus on the diagnostic criteria for multiple system atrophy (2017) or the International Society for Parkinson\'s Disease and Movement Disorders (MDS) diagnostic criteria for multiple system atrophy (2022)
• ③ MSA subtype grouping: MSA is divided into MSA-P and MSA-C subtypes based on the severity of initial and/or motor symptoms, with Patients with Parkinson\'s syndrome as the main type are MSA-P, while patients with cerebellar syndrome as the main type are MSA-C.
• Age range from 45 to 80 years old;
• ② PSP patients who meet the diagnostic criteria for progressive supranuclear palsy in China (2016) or the diagnostic criteria for progressive supranuclear palsy in the International Society for Parkinson\'s Disease and Movement Disorders (MDS) (2017)
• (3) Selection criteria for Parkinson\'s disease case group
• Age range from 45 to 80 years old;
• Patients with idiopathic Parkinson\'s disease who meet the diagnostic criteria of the International Committee on Motor Disorders (MDS) for Parkinson\'s disease (2015);
• Classification criteria for subtypes of Parkinson\'s disease:
• Tremor predominant type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≥ 1.15
• PIGD type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≤ 0.9

You may not qualify if:

• ① Hereditary Parkinson\'s syndrome, secondary Parkinson\'s syndrome.
• After deep brain stimulation (DBS) surgery.
• Have a history of malignant tumors.

Sponsors & Collaborators

• Fujian Medical University Union Hospital: lead

Study Sites (1)

Fujian Medical University Union Hospital

Fuzhou, Fujian, 350000, China

RECRUITING

MeSH Terms

Conditions

Supranuclear Palsy, Progressive; Multiple System Atrophy; Parkinson Disease

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Ophthalmoplegia; Ocular Motility Disorders; Cranial Nerve Diseases; Tauopathies; Neurodegenerative Diseases; Paralysis; Neurologic Manifestations; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Primary Dysautonomias; Autonomic Nervous System Diseases; Synucleinopathies; Parkinsonian Disorders

Central Study Contacts

Ying Chen associate chief physician, Master

CONTACT

13365910067; 2320609050@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 1, 2024
• First Posted: July 8, 2024
• Study Start: February 1, 2023
• Primary Completion: June 30, 2024
• Study Completion: February 1, 2026
• Last Updated: July 8, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)