Factors Influencing the Mortality of Patients With Subarachnoid Haemorrhage

NCT06490640 | Completed

• 1 other identifier: Akdeniz U.
• Study Type: observational
• Target: 117
• Locations: 1 country
• Sites: 1

Brief Summary

Spontaneous subarachnoid haemorrhage (SAH) is a serious cerebrovascular disease with high morbidity and mortality.Determining the factors associated with mortality in the ICU follow-up and treatment of patients with spontaneous SAH is very important for clarifying these uncertainties and improving ICU outcomes.In the literature, there are very few studies analysing ICU mortality and mortality-related factors in this patient group.The aim of this study was to determine the demographic/clinical characteristics and factors affecting the mortality of spontaneous SAH patients admitted in the ICU.

Conditions

Spontaneous Subarachnoid Hemorrhage

Keywords

Intensive Care Unit; Mortality; Spontaneous subarachnoid haemorrhage

Outcome Measures

Primary Outcomes (1)

• determine mortality and causes

  determine mortality and its causes in patients with spontaneous subarachnoid haemorrhage

  01 January 2019-31 December 2023

Secondary Outcomes (1)

• factors affecting mortality

  01 January 2019-31 December 2023

Study Arms (2)

Spontaneous subarachnoid haemorrhage survival cohort

Demographic and clinical data derived and analyzed included age, sex, smoking history, comorbidities. Presenting signs and symptoms, diagnoses responsible for spontaneous SAH (aneurysm, arterial malformation, etc.), site of aneurysm, risk factors, location of the aneurysm, risk factors, blood pressure during ICU admission, and scores from grading systems indicating clinical and radiological severity of the disease were recorded. Procedures for spontaneous SAH, complications during ICU follow-up (vasospasm, meningitis, electrolyte disturbances, rebleeding, DCI, VIP, sepsis/septic shock) and treatments, duration of ICU stay and mechanical ventilation, ICU outcome (survival or mortality), causes of mortality and brain death status were recorded.

Other: Spontaneous subarachnoid haemorrhage survival cohort

Spontaneous subarachnoid haemorrhage mortality cohort

Demographic and clinical data derived and analyzed included age, sex, smoking history, comorbidities. Presenting signs and symptoms, diagnoses responsible for spontaneous SAH (aneurysm, arterial malformation, etc.), site of aneurysm, risk factors, location of the aneurysm, risk factors, blood pressure during ICU admission, and scores from grading systems indicating clinical and radiological severity of the disease were recorded. Procedures for spontaneous SAH, complications during ICU follow-up (vasospasm, meningitis, electrolyte disturbances, rebleeding, DCI, VIP, sepsis/septic shock) and treatments, duration of ICU stay and mechanical ventilation, ICU outcome (survival or mortality), causes of mortality and brain death status were recorded.

Other: Spontaneous subarachnoid haemorrhage mortality cohort

Interventions

Spontaneous subarachnoid haemorrhage survival cohort OTHER

consists of surviving patients

Spontaneous subarachnoid haemorrhage survival cohort

Spontaneous subarachnoid haemorrhage mortality cohort OTHER

consists of deceased patients

Spontaneous subarachnoid haemorrhage mortality cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 18 years and older who were diagnosis of spontaneous SAH and admitted the intensive care unit were included in the study.

You may qualify if:

• Patients aged ≥18 years with a confrmed diagnosis of spontaneous subarachnoid haemorrhage by a brain computed tomography (CT)
• Patients with a final outcome (survival or mortality) in our centre

You may not qualify if:

• Patients with traumatic SAH
• History of significant head trauma in the previous two weeks (any abnormality on brain CT requiring hospitalisation for more than 24 hours)
• Pregnancy
• Length of intensive care unit stay ≤24 hours

Sponsors & Collaborators

• Melike Cengiz: lead

Study Sites (1)

Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey

Antalya, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Subarachnoid Hemorrhage

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ulku Arslan Yildiz, MD

  Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey

  PRINCIPAL INVESTIGATOR

• Murat Yilmaz, Professor

  Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey

  PRINCIPAL INVESTIGATOR

• Onur Cetinkaya, MD

  Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MD,Professor Doctor

Study Record Dates

• First Submitted: June 29, 2024
• First Posted: July 8, 2024
• Study Start: March 1, 2024
• Primary Completion: May 1, 2024
• Study Completion: June 15, 2024
• Last Updated: July 8, 2024

Record last verified: 2024-06

Locations

TU (1)