Long-term Effects of Time to Treatment in Subarachnoid Haemorrhage

NCT04377347 | Completed

• 1 other identifier: Outcome
• Study Type: observational
• Target: 537
• Locations: 1 country
• Sites: 1

Brief Summary

For patients with spontaneous subarachnoid haemorrhage, it remains to be investigated if there is an association between the time from patients call the Emergence Medical Coordination Center to neurosurgical admission and long-term outcome. This is a retrospective cohort study with four-year followup. The primary aim is to determine if the time to neurosurgical admission is associated to labour marked affiliation and mortality after four years.

Conditions

Spontaneous Subarachnoid Hemorrhage

Outcome Measures

Primary Outcomes (1)

• Labour marked affiliation and mortality

  The incidence of all-cause death and early retirement over the four-years after sSAH for different times to treatment is shown with Kaplan-Meier plots, and assessed with log-rank tests.

  4 years

Study Arms (1)

Confirmed spontaneous subarachnoid haemorrhage

Patients, minimum 18 years of age, identified with the diagnosis in the Danish National Patient Register. The diagnosis is verified by medical record review. All patients were initially admitted to a hospital in the Capital Region of Denmark. In a national labour marked register and the civil registration register the patients are then followed for four years.

Other: Time

Interventions

Time OTHER

Exposure is the time from patients call the Emergency Medical Coordination Center to they are admitted to a neurosurgiocal department.

Confirmed spontaneous subarachnoid haemorrhage

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients that are retired or on social transfer payments the last three months before the sSAH are excluded from analyses on retirement and labour marked affiliation. However, they are included in mortality analyses. Also, patients aged 60 years or older are excluded in analyses of early retirement as reduced work capacity may to a higher degree result in early voluntary retirement.

You may qualify if:

• Spontaneous subarachnoid haemorrhage registered in the Danish National Patient Register and confirmed by medical record review.
• Initially admitted to a hospital in the Capital Region of Denmark between 1 January 2008 and 31 December 2014.

You may not qualify if:

• Prior subarachnoid haemorrhage.
• Inhospital symptom onset.

Sponsors & Collaborators

• Rigshospitalet, Denmark: lead

Study Sites (1)

Rigshospitalet

Copenhagen, Denmark

Location

MeSH Terms

Conditions

Subarachnoid Hemorrhage

Interventions

Time

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Physical Phenomena

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 4 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: May 2, 2020
• First Posted: May 6, 2020
• Study Start: May 1, 2020
• Primary Completion: February 24, 2021
• Study Completion: February 24, 2021
• Last Updated: February 25, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)