NCT06489938

Brief Summary

The goal of this clinical trial is to examine the effects of mirror therapy combined with task- vs. Impairment-oriented rehabilitation programs as novel hybrid approaches in individuals with stroke. Participants will receive mirror therapy combined with the task-oriented rehabilitation program (MTT), mirror therapy combined with the impairment-oriented rehabilitation program (MTI), or task-oriented rehabilitation program combined with the impairment-oriented rehabilitation program (TI) 90 minutes per day, three days per week, for six weeks.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
123

participants targeted

Target at P50-P75 for not_applicable cardiovascular-diseases

Timeline
56mo left

Started Jul 2024

Longer than P75 for not_applicable cardiovascular-diseases

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress28%
Jul 2024Dec 2030

First Submitted

Initial submission to the registry

June 29, 2024

Completed
2 days until next milestone

Study Start

First participant enrolled

July 1, 2024

Completed
7 days until next milestone

First Posted

Study publicly available on registry

July 8, 2024

Completed
6.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2030

Last Updated

July 8, 2024

Status Verified

June 1, 2024

Enrollment Period

6.5 years

First QC Date

June 29, 2024

Last Update Submit

June 29, 2024

Conditions

Keywords

RehabilitationMirror Therapy

Outcome Measures

Primary Outcomes (4)

  • Fugl-Meyer Assessment

    A standardized tool for evaluating motor impairment for stroke

    Baseline, six weeks, and 3 months after completing the intervention

  • Revised Nottingham Sensory Assessment

    A standardized tool for evaluating sensory impairment for stroke

    Baseline, six weeks, and 3 months after completing the intervention

  • Chedoke Arm and Hand Activity Inventory

    An assessment for bilateral functional abilities

    Baseline, six weeks, and 3 months after completing the intervention

  • Wolf Motor Function Test

    An assessment for both unilateral and bilateral functional abilities

    Baseline, six weeks, and 3 months after completing the intervention

Secondary Outcomes (11)

  • Grip and pinch power

    Baseline, six weeks, and 3 months after completing the intervention

  • Box and block test

    Baseline, six weeks, and 3 months after completing the intervention

  • Ten-meter walk test

    Baseline, six weeks, and 3 months after completing the intervention

  • Berg Balance Scale

    Baseline, six weeks, and 3 months after completing the intervention

  • Motor Activity Log

    Baseline, six weeks, and 3 months after completing the intervention

  • +6 more secondary outcomes

Study Arms (3)

Mirror therapy combined with the task-oriented approach (MTT)

EXPERIMENTAL

Each participant will receive the mirror therapy combined with the task-oriented approach 90 minutes daily, three days per week for six weeks.

Behavioral: Mirror therapyBehavioral: Task-oriented approach

Mirror therapy combined with the impairment-oriented approach (MTI)

EXPERIMENTAL

Each participant will receive the mirror therapy combined with the impairment-oriented approach 90 minutes daily, three days per week for six weeks.

Behavioral: Mirror therapyBehavioral: Impairment-oriented approach

Task-oriented rehabilitation program combined with impairment-oriented rehabilitation program (TI)

ACTIVE COMPARATOR

Each participant will receive the task-oriented rehabilitation program combined with the impairment-oriented rehabilitation program 90 minutes daily, three days per week for six weeks.

Behavioral: Task-oriented approachBehavioral: Impairment-oriented approach

Interventions

Mirror therapyBEHAVIORAL

In mirror therapy, a wooden mirror (41×50×33 cm3) will be positioned in the participant's sagittal midplane, blocking the participant's view of the affected arm performance. We will also provide a foldable bed tray table to ensure that the participants focus on the mirror reflection of the less affected arm. The mirror therapy will consist of movement and functional practices.

Mirror therapy combined with the impairment-oriented approach (MTI)Mirror therapy combined with the task-oriented approach (MTT)

The task-oriented approach will provide both bimanual common-goal and dual-goal tasks for the participants.

Mirror therapy combined with the task-oriented approach (MTT)Task-oriented rehabilitation program combined with impairment-oriented rehabilitation program (TI)

The impairment-oriented approach will focus on the movement components. Arm BASIS or Arm Ability training will be provided based on the severity of the participant's impairment.

Mirror therapy combined with the impairment-oriented approach (MTI)Task-oriented rehabilitation program combined with impairment-oriented rehabilitation program (TI)

Eligibility Criteria

Age20 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • A first-ever unilateral stroke ≥3 months
  • Age between 20 and 80 years
  • Baseline Fugl-Meyer Assessment Upper Extremity (FMA-UE) score \>10
  • No severe spasticity in any joints of the affected arm
  • Ability to follow the instructions
  • No participation in other studies during the study period
  • Willingness to provide informed written consent.

You may not qualify if:

  • \. Serious medical problems or poor physical conditions that might be detrimental to study participation.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Cardiovascular DiseasesStrokeCerebrovascular Disorders

Interventions

Mirror Movement Therapy

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular Diseases

Intervention Hierarchy (Ancestors)

Physical Therapy ModalitiesRehabilitationTherapeutics

Study Officials

  • Yi-chun Li, Doctor

    I-Shou University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Yi-chun Li, Doctor

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Neuro-Rehabilitation Research Laboratory (NRRL)

Study Record Dates

First Submitted

June 29, 2024

First Posted

July 8, 2024

Study Start

July 1, 2024

Primary Completion (Estimated)

December 31, 2030

Study Completion (Estimated)

December 31, 2030

Last Updated

July 8, 2024

Record last verified: 2024-06

Data Sharing

IPD Sharing
Will not share