Survival and cArdiovascular eVents in Patients With Acute Myocardial Infarction

NCT06489080 | Recruiting

• 1 other identifier: 2024yan097-002
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective and prospective cohort study aims to establish a long-term follow-up cohort of patients with acute myocardial infarction, and combine multi-omics studies, wearable devices, artificial intelligence technology, etc., to describe the clinical characteristics of patients with acute myocardial infarction and the changing trend of treatment strategies, and analyze the related influencing factors. Explore new biomarkers and indicators affecting recurrent cardiovascular events for accurate risk stratification and risk prediction; To evaluate the factors affecting lifestyle intervention, drug efficacy and safety, and their impact on outcome, and improve chronic disease management mode, in order to improve the quality of life and prognosis of patients.

Conditions

Acute Myocardial Infarction; Coronary Artery Disease

Keywords

Acute Myocardial Infarction; Coronary Artery Disease; cohort study

Outcome Measures

Primary Outcomes (1)

• Major Adverse Cardiovascular Events

  Composite end points of Cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke

  5 years

Secondary Outcomes (1)

• Secondary Adverse Cardiovascular Events

  5 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalized in the department of Cardiology or outpatient department of Peking University First Hospital will be enrolled if they are aged ≥18 years old, meet the inclusion criteria of acute myocardial infarction and need long-term follow-up according to the judgment of doctors after informed consent. There are about 7500 retrospectively enrolled patients, and it is expected to enroll 500 patients per year.

You may qualify if:

• Acute myocardial infarction is diagnosed meets the universal definition of acute myocardial infarction

You may not qualify if:

• Did not agree to participate in the study

Sponsors & Collaborators

• Peking University First Hospital: lead

Study Sites (1)

Division of Cardiology, Peking University First Hospital

Beijing, Beijing Municipality, 100034, China

RECRUITING

Related Publications (3)

• Li J, Li X, Wang Q, Hu S, Wang Y, Masoudi FA, Spertus JA, Krumholz HM, Jiang L; China PEACE Collaborative Group. ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data. Lancet. 2015 Jan 31;385(9966):441-51. doi: 10.1016/S0140-6736(14)60921-1. Epub 2014 Jun 23.

  PMID: 24969506 BACKGROUND

• Xu H, Yang Y, Wang C, Yang J, Li W, Zhang X, Ye Y, Dong Q, Fu R, Sun H, Yan X, Gao X, Wang Y, Jia X, Sun Y, Wu Y, Zhang J, Zhao W, Sabatine MS, Wiviott SD; China Acute Myocardial Infarction Registry Investigators. Association of Hospital-Level Differences in Care With Outcomes Among Patients With Acute ST-Segment Elevation Myocardial Infarction in China. JAMA Netw Open. 2020 Oct 1;3(10):e2021677. doi: 10.1001/jamanetworkopen.2020.21677.

  PMID: 33095249 BACKGROUND

• Hao Y, Zhao D, Liu J, Liu J, Yang N, Huo Y, Fonarow GC, Ge J, Morgan L, Ma C, Han Y, Smith SC Jr; CCC-ACS Investigators. Performance of Management Strategies With Class I Recommendations Among Patients Hospitalized With ST-Segment Elevation Myocardial Infarction in China. JAMA Cardiol. 2022 May 1;7(5):484-491. doi: 10.1001/jamacardio.2022.0117.

  PMID: 35293976 BACKGROUND

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Central Study Contacts

Jia Jia, MPH

CONTACT

861083572283; jiajia9985@163.com

Bin Zhang, MD

CONTACT

861083572645; raisend0101@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Department of Cardiology

Study Record Dates

• First Submitted: June 23, 2024
• First Posted: July 5, 2024
• Study Start: March 1, 2024
• Primary Completion: December 31, 2024
• Study Completion (Estimated): December 31, 2028
• Last Updated: July 5, 2024

Record last verified: 2024-07

Locations

CN (1)