LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
LAMI
2 other identifiers
observational
105
1 country
2
Brief Summary
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jul 2024
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 13, 2024
CompletedFirst Posted
Study publicly available on registry
June 27, 2024
CompletedStudy Start
First participant enrolled
July 27, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 26, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 26, 2028
August 2, 2024
August 1, 2024
3 years
June 13, 2024
August 1, 2024
Conditions
Outcome Measures
Primary Outcomes (2)
Level of corticospinal excitability
this is a physiological response obtained by transcranial magnetic pulses (TMS). This is an indicator of the excitability of the motor system, which can be used at rest or during various cognitive tasks (motor imagery or action reading).
1 hour and 30 minutes
Cortical activation (BOLD signal)
this is a cortical response obtained via a fMRI. This is an indicator of the brain activity, which can be used at rest or during motor and cognitive tasks (motor imagery or action reading).
1 hour
Study Arms (5)
TMS Experimental group
fMRI Experimental group
Experimental ccPAS group
Sham ccPAS group
control group
Interventions
Participants were asked to imagine arm or foot movements.
Participants were asked to read sentences involving arm or foot movements
Eligibility Criteria
Subjects will be aged between 18 and 40, reading and understanding French, with no neurological or psychiatric disorders, no uncorrected vision deficits, and meeting all MRI or TMS examination criteria. they were recruited at the University of Burgundy (TMS measures only) and the University of Grenoble Alpes (fMRI measures only).
You may qualify if:
- persons who have given written consent,
- healthy subjects
- subjects reading and understanding French
- right-handed,
- affiliated with a social security system,
- between 18 and 40 years old,
You may not qualify if:
- Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
- Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
- Characterized psychiatric pathology,
- Ingestion of alcohol prior to the examination,
- Persons covered by articles L1121-5 to L1121-8 of the CSP,
- Presence of contraindications to MRI or TMS.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University Hospital, Grenoblelead
- University of Burgundycollaborator
Study Sites (2)
CHU Grenoble Alpes
Grenoble, Grenob, 38043, France
Université de Bourgogne
Dijon, France
Study Officials
- PRINCIPAL INVESTIGATOR
Laurent VERCUEIL
CHU Grenoble Alpes
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 13, 2024
First Posted
June 27, 2024
Study Start
July 27, 2024
Primary Completion (Estimated)
July 26, 2027
Study Completion (Estimated)
July 26, 2028
Last Updated
August 2, 2024
Record last verified: 2024-08