The Coastal Exposome: a Study of Sea Air Inhalation and Possible Links to Health

NCT06477627 | Active Not Recruiting

• 1 other identifier: ONZ-2024-0078
• Study Type: interventional
• Target: 67
• Locations: 1 country
• Sites: 1

Brief Summary

The research aims to understand oceans as crucial contributors to human health in coastal environments. Oceans produce marine spray aerosols that contain a mixture of microbiota and natural biological molecules (biogenics).

Conditions

Difference Between Coastal and Inland Populations

Keywords

Oceans and human health

Outcome Measures

Primary Outcomes (4)

• nose swabs: respiratory microbiome and biogenics profile

  DNA from the nose swabs will be analysed using sequencing for analyzing the microbiome. Biogenics on the swabs will be analysed as well, to get an idea of what molecules and microbiota from the sea air are inhaled. This will happen with UPLC-QTOF-MS.

  4 times during the 8 week study period

• VAMS blood samples: cytokines

  Cytokines will be measured in blood samples to link the sea air exposure to the human health. A multiplex kit will be used to measure 20 cytokines.

  4 times during the 8 week study period

• GPS

  via sensorlogger app on their phone, to collect GPS data when outside.

  during the 8 week study period, if more than 15 minutes spend outside

• questionnaires

  Filling in a questionnaire via qualtrics

  at the start, in the middle and at the end of the 8 weeks.

Study Arms (3)

group lives inland, but spends a lot of time at the coast during study period

OTHER

This group lives inland, but spends a lot of time at the coast during the study period.

Other: no intervention

reference group coast

OTHER

This group lives at the coast the whole year round

Other: no intervention

reference group inland

OTHER

This group lives inland all year round.

Other: no intervention

Interventions

no intervention OTHER

no intervention, people just indicate if they spend time inland or at the coast

group lives inland, but spends a lot of time at the coast during study period; reference group coast; reference group inland

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy participants between 18 and 50 years old

You may not qualify if:

• people with a medical condition
• people younger than 18 and older than 50

Sponsors & Collaborators

• University Ghent: lead

Study Sites (1)

Ghent University

Ghent, Oost-Vlaanderen, 9000, Belgium

Location

Study Officials

• Hannelore Denys

  University Ghent

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: three groups: one group that lives at the coast all year round, one group that lives inland all year round and one group that live inland but spend a lot of time at the coast in the summer. The participants will not get any treatment, they just live in different regions.

Study Record Dates

• First Submitted: June 21, 2024
• First Posted: June 27, 2024
• Study Start: June 19, 2024
• Primary Completion: October 31, 2024
• Study Completion (Estimated): October 31, 2026
• Last Updated: June 3, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)