Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies

NCT01919957 | Completed

• 2 other identifiers: C12-112013-A00343-42
• Study Type: observational
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies. Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.

Conditions

Epilepsy, Unspecified, Pharmacologically Resistant; Memory Impairment

Keywords

epilepsy; surgery; functional MRI; memory outcome

Outcome Measures

Primary Outcomes (1)

• Measure of successfull encoding

  Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI

  8 years

Study Arms (1)

memory outcome

Interventions

No intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The research requires the inclusion of healthy volunteers (controls) and epileptic patients

You may qualify if:

• Patients with drug-resistant epilepsy
• Age of 18 years or more
• Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
• Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
• Covered by a social security system
• Signing of consent form

You may not qualify if:

• Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
• Refusal to consent form
• Contraindications to MRI
• Pregnancy
• Refusal to be informed in the case of detection of an abnormality during the experiment

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

INSERM - Plateau IRM du CENIR, CR-ICM Hôpital Pitié-Salpêtrière, 47/83 Boulevard de l'Hôpital

Paris, 75651 Cedex 13, France

Location

MeSH Terms

Conditions

Epilepsy; Memory Disorders

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Sophie Dupont, MD, PhD

  Service de Soins de Suites et Réadaptation Neurologique, Hôpital de la Pitié-Salpêtrière, 47/83 Bd de l'Hôpital, 75651 Paris Cedex 13

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 1, 2013
• First Posted: August 9, 2013
• Study Start: October 10, 2013
• Primary Completion: October 9, 2021
• Study Completion: October 9, 2022
• Last Updated: September 24, 2026

Record last verified: 2025-04

Locations

FR (1)