Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies
MemO-Epi
Etude de la mémoire Avant et après Chirurgie d'Une épilepsie Partielle pharmacorésistante : Bases Neurobiologiques, Applications Cliniques
2 other identifiers
interventional
120
1 country
1
Brief Summary
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies. Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Oct 2013
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 1, 2013
CompletedFirst Posted
Study publicly available on registry
August 9, 2013
CompletedStudy Start
First participant enrolled
October 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2022
CompletedFebruary 6, 2015
February 1, 2015
8.2 years
July 1, 2013
February 5, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Measure of successfull encoding
Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI
8 years
Study Arms (1)
memory outcome
NO INTERVENTIONInterventions
Eligibility Criteria
You may qualify if:
- Patients with drug-resistant epilepsy
- Age of 18 years or more
- Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
- Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
- Covered by a social security system
- Signing of consent form
You may not qualify if:
- Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
- Refusal to consent form
- Contraindications to MRI
- Pregnancy
- Refusal to be informed in the case of detection of an abnormality during the experiment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
INSERM - Plateau IRM du CENIR, CR-ICM Hôpital Pitié-Salpêtrière, 47/83 Boulevard de l'Hôpital
Paris, Cedex 13, 75651, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sophie Dupont, MD, PhD
Service de Soins de Suites et Réadaptation Neurologique, Hôpital de la Pitié-Salpêtrière, 47/83 Bd de l'Hôpital, 75651 Paris Cedex 13
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 1, 2013
First Posted
August 9, 2013
Study Start
October 1, 2013
Primary Completion
December 1, 2021
Study Completion
December 1, 2022
Last Updated
February 6, 2015
Record last verified: 2015-02