The Influence of Menopausal Status on Myocardial Stiffness and Exercise Capacity Among Female Masters Endurance Athletes.
1 other identifier
observational
48
1 country
1
Brief Summary
The purpose of this research is to study postmenopausal female masters athletes to see if they will show greater myocardial stiffness and reduced exercise capacity than premenopausal females and similarly aged male masters athletes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Sep 2024
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 21, 2024
CompletedFirst Posted
Study publicly available on registry
June 26, 2024
CompletedStudy Start
First participant enrolled
September 14, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 6, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
October 6, 2025
CompletedNovember 6, 2025
November 1, 2025
1.1 years
June 21, 2024
November 4, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Myocardial stiffness
Myocardial stiffness will be measured by magnetic resonance elastography (kPa)
Day 14
Secondary Outcomes (2)
Left ventricular filling pressures with exercise
Baseline
Exercise capacity
Baseline
Study Arms (3)
Premenopausal Female Athletes
Postmenopausal Female Athletes
Male Athletes
Interventions
Exercise testing via treadmill with simultaneous gas exchange analysis and pre- and post-exercise transthoracic echocardiography.
Non-invasive imaging scan used to examine function and structure of the heart
Non-invasive imaging scan used to measure myocardial stiffness
Eligibility Criteria
Masters athletes (40-70 yrs of age) with a longstanding history of competitive endurance athletic performance defined as \>15 years of continuous athletic training for at least 7 hours per week, and ongoing engagement in competitive events, will be recruited from Mayo registry and from the local athletic community via brochures within the Dan Abraham Healthy Living Center and the Mayo Clinic Classifieds.
You may qualify if:
- Longstanding history of competitive endurance athletic performance defined as \>15 years of continuous athletic training for at least 7 hours per week and ongoing engagement in competitive events.
You may not qualify if:
- A current or prior diagnosis of cardiovascular disease as defined by the presence of structural heart disease, heart failure, symptomatic coronary artery disease, more than moderate valve disease or prior valve surgery,
- Current or recent pregnancy within 1 year
- Positive pregnancy test (study visit 1)
- Concurrent or use within 1 year of oral contraceptives or hormone replacement therapy,
- Unable to undergo a cMRI (Please refer standard clinical contraindications for MRI)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mayo Cliniclead
Study Sites (1)
Mayo Clinic
Rochester, Minnesota, 55905, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kathryn Larson, MD
Mayo Clinic
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Senior Associate Consultant, Cardiovascular Medicine
Study Record Dates
First Submitted
June 21, 2024
First Posted
June 26, 2024
Study Start
September 14, 2024
Primary Completion
October 6, 2025
Study Completion
October 6, 2025
Last Updated
November 6, 2025
Record last verified: 2025-11
Data Sharing
- IPD Sharing
- Will not share