Online Exposure Therapy for Obsessive-Compulsive Disorder (OCD) Study

NCT06470893 | Completed

• 1 other identifier: 20240483
• Study Type: interventional
• Target: 63
• Locations: 1 country
• Sites: 1

Brief Summary

The overarching goal of this protocol is to investigate mechanisms that influence symptom outcomes of exposure and response prevention (ERP) therapy for OCD. Mechanisms may include affective processes, learning factors, cognitive factors, or other constructs that could influence treatment outcomes. The study team will conduct this research within the context of an effective online treatment for OCD called OCD-NET. OCD-NET is bibliotherapy with coaching and its content is reflective of standard care for OCD.

Conditions

Obsessive-Compulsive Disorder

Outcome Measures

Primary Outcomes (1)

• Change in OCD Symptoms Measured by Yale-Brown Obsessive Compulsive Scale-Second Edition (YBOCS-II)

  YBOCS-II scores range from 0-50, and higher scores indicate more severe illness

  Baseline, up to 12 months (end of treatment)

Study Arms (1)

OCD-NET Group

EXPERIMENTAL

Participants will receive the OCD-NET intervention for up to 12 months.

Behavioral: OCD-NET

Interventions

OCD-NET BEHAVIORAL

OCD-NET is bibliotherapy with coaching and its content is reflective of standard care for OCD. OCD-NET is a self-paced intervention that participants complete entirely online with the support of an assigned individual therapist. Most participants complete this treatment in up to twelve weeks. On average, participants are expected to spend between one to five hours per week during the first half of treatment. In the second half of treatment when participants begin regular exposure and response prevention (ERP) exercises, participants are expected to spend about one hour per day.

OCD-NET Group

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• English-speaking
• Located within the United States
• years old
• Able to provide consent
• Current diagnosis of OCD as assessed by clinical interview

You may not qualify if:

• Adults unable to consent
• Individuals who are not yet adults (infants, children, teenagers)
• Participants currently located outside of the United States
• Prisoners
• Participants with hoarding as the primary OCD symptom
• Severe mental illness (e.g. schizophrenia, substance abuse); organic brain syndrome; or serious, current suicidal/homicidal ideation (based on phone screening or initial assessment)
• Concurrent enrollment in another psychotherapy treatment
• Participants taking psychotropic medication may be excluded if:
• They have started a brand new psychotropic medication within the last 12 weeks
• They have changed the dose of their psychotropic medication within the last 4 weeks
• They anticipate that they cannot maintain the current dose of their psychotropic medication for the duration of the study
• Participants may be excluded if they have any cognitive or physical impairments that would interfere with their participation (e.g., significant head injury, cognitive disability, dementia).

Sponsors & Collaborators

• University of Miami: lead

Study Sites (1)

University of Miami

Miami, Florida, 33146, United States

Location

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders

Study Officials

• Kiara Timpano, PhD

  University of Miami

  STUDY CHAIR

• Amelia Dev, MS

  University of Miami

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 17, 2024
• First Posted: June 24, 2024
• Study Start: September 23, 2024
• Primary Completion: July 8, 2025
• Study Completion: July 23, 2025
• Last Updated: August 19, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)