Light Therapy for Obsessive-compulsive Disorder (OCD)

NCT05391503 | Completed

• 1 other identifier: 270-FP-22
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the effect of a light-based circadian treatment on OCD symptoms in adults with OCD and late bedtimes. This study will have important implications for understanding the role of circadian rhythms in the etiology and treatment of OCD.

Conditions

Obsessive-Compulsive Disorder

Keywords

circadian; sleep; anxiety; OCD

Outcome Measures

Primary Outcomes (1)

• Obsessive-Compulsive Inventory-Revised score

  Self-reported OCD symptoms. Minimum score=0, maximum score=74. Higher scores indicate worse outcome

  3 weeks

Secondary Outcomes (1)

• Yale-Brown Obsessive-Compulsive Scale score

  5 weeks

Other Outcomes (1)

• Circadian phase

  3 weeks

Study Arms (2)

Active treatment

ACTIVE COMPARATOR

Active light therapy

Behavioral: Light therapy

Control treatment

PLACEBO COMPARATOR

Placebo light therapy

Behavioral: Placebo light therapy

Interventions

Light therapy BEHAVIORAL

Morning bright light for 60 minutes after awakening

Active treatment

Placebo light therapy BEHAVIORAL

Placebo morning bright light for 60 minutes after awakening

Control treatment

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Primary OCD diagnosis (according to the Diagnostic and Statistical Manual of Mental Disorders 5)
• Bedtime 0100 or later
• Age 18-35
• English speaking

You may not qualify if:

• Subjects must not be currently participating in another research study that would influence their participation in our study.
• Past 6-month substance use disorder
• Lifetime psychosis or bipolar disorder
• Current sleep disorder (DSWPD and insomnia excepted)
• Significant, active suicidal ideation or behaviors in the past 6 months
• Intellectual disability
• Engaged in evidence-based psychotherapy for OCD
• History of light therapy or cognitive behavior therapy for insomnia
• Night shift work or travel outside of Mountain Standard Time in the past month
• Pregnant, trying to become pregnant, or breastfeeding
• Change in psychotropic medication in the past month
• Prescribed or over the counter sleep medication use in the past month
• Beta-block or monoamine oxidase inhibitor use in the past month

Sponsors & Collaborators

• University of Colorado, Boulder: lead

Study Sites (1)

Sleep and Chronobiology Laboratory

Boulder, Colorado, 80309-0554, United States

Location

MeSH Terms

Conditions

Obsessive-Compulsive Disorder; Anxiety Disorders

Interventions

Phototherapy

Condition Hierarchy (Ancestors)

Mental Disorders

Intervention Hierarchy (Ancestors)

Therapeutics

Study Officials

• Rebecca C Cox, PhD

  University of Colorado, Boulder

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postdoctoral fellow

Study Record Dates

• First Submitted: May 20, 2022
• First Posted: May 26, 2022
• Study Start: September 23, 2022
• Primary Completion: August 31, 2024
• Study Completion: August 31, 2024
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will share

Locations

US (1)