Appendicoliths in Acute Complicated Appendicitis Patients With Abscess

NCT06469086 | Not Yet Recruiting

• 1 other identifier: Zhongshan-HHY-05
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Complicated appendicitis, characterized by the presence of an abscess or perforation, involves acute inflammation of the peritoneum secondary to an infection of the appendix, presenting additional challenges for management. Traditionally, the standard treatment for complicated appendicitis has been surgical intervention. However, conservative management, involving antibiotics and drainage, has emerged as a viable alternative for selected patients. Recent studies emphasize the importance of selecting appropriate antibiotics based on local resistance patterns and the patient's clinical condition. Broad-spectrum antibiotics, including those targeting anaerobic bacteria, are often preferred. In addition, advances in imaging technology, such as ultrasound-guided drainage, have improved the precision and success rates of percutaneous abscess drainage. This minimally invasive approach helps manage localized infections and can prevent the need for immediate surgery. One factor that has gained significant attention in determining the success of conservative treatment for acute complicated appendicitis is the presence of appendicoliths-calcified deposits within the appendix. This study aims to investigate the clinical significance of appendicoliths in the conservative management of acute complicated appendicitis with abscesses.

Conditions

Acute Complicated Appendicitis With Abscess

Outcome Measures

Primary Outcomes (1)

• The success rate of conservative treatment

  January 01, 2025 to December 31, 2025.

Secondary Outcomes (3)

• Postoperative complications

  January 01, 2025 to December 31, 2025.

• Length of postoperative hospital stay

  January 01, 2025 to December 31, 2025.

• The surgical approach used

  January 01, 2025 to December 31, 2025.

Interventions

Clinical data collection OTHER

The clinical significance of appendicoliths in the conservative management of acute complicated appendicitis with abscesses.

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Acute complicated appendicitis patients with absces swho met the criteria.

You may qualify if:

• Patients who aged ≥18 years, who diagnosed as acute appendicitis clinically, who had peri-appendiceal abscess larger than 2 cm in diameter on CT scan, who agreed conservative treatment first, who refused immediate emergency surgery

You may not qualify if:

• Patients younger than 18 years, those with malignancies, those with incomplete clinical or pathological records were excluded from the study

Sponsors & Collaborators

• Shanghai Zhongshan Hospital: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2024
• First Posted: June 21, 2024
• Study Start: January 1, 2025
• Primary Completion: December 31, 2025
• Study Completion (Estimated): December 31, 2026
• Last Updated: June 24, 2024

Record last verified: 2024-06