Advanced Glycation Products and Vascular Complications in Type 1 Diabetes

NCT06458088 | Recruiting

• 1 other identifier: PA23009
• Study Type: observational
• Target: 196
• Locations: 1 country
• Sites: 1

Brief Summary

DIABAGE (Diabetes Advanced Glycation End products) study was conducted between 2015 and 2017. It included 196 type 1 diabetic patients with more than 10 years of diabetes. It revealed a significant association between the occurrence of vascular complications and tissular Advanced Glycation End products (AGEs) as well as with some circulating AGEs. This protocol is a continuation of that initial research.

Conditions

Type1diabetes

Keywords

Vascular complication; Diabetic retinopathy; Diabetic nephropathy; Diabetic neuropathy; Cardio-vascular events; Advanced Glycation End Products; AGE

Outcome Measures

Primary Outcomes (1)

• Association between baseline AGE values and incident cases of vascular complications.

  * Occurrence of a cardiovascular event. * Appearance or aggravation of ophthalmological involvement. * Appearance or worsening of diabetic nephropathy. * Appearance of diabetic neuropathy.

  At inclusion

Secondary Outcomes (2)

• The correlation between the tissue AGE deltas (defined by the difference between the AGEs at 5 years and the initial AGEs) and the cumulative HbA1c over the 5 years.

  At inclusion

• The association between baseline AGE values and the occurrence of macrovascular damage.

  At inclusion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

* Inclusion in initial DIABAGE study. * Follow-up at Reims hospital.

You may qualify if:

• Follow-up at Reims hospital.

You may not qualify if:

• \- Refusal to participate.

Sponsors & Collaborators

• CHU de Reims: lead

Study Sites (1)

Chu Reims

Reims, 51092, France

RECRUITING

Related Publications (1)

• Diallo AM, Jaisson S, Barriquand R, Lukas C, Barraud S, Decoudier B, Francois M, Ly S, Mahmoudi R, Arndt C, Nazeyrollas P, Gillery P, Delemer B. Association Between the Tissue and Circulating Advanced Glycation End-Products and the Micro- and Macrovascular Complications in Type 1 Diabetes: The DIABAGE Study. Diabetes Ther. 2022 Aug;13(8):1531-1546. doi: 10.1007/s13300-022-01285-1. Epub 2022 Jul 2.

  PMID: 35779209 BACKGROUND

MeSH Terms

Conditions

Diabetic Retinopathy; Diabetic Nephropathies; Diabetic Neuropathies

Condition Hierarchy (Ancestors)

Retinal Diseases; Eye Diseases; Diabetic Angiopathies; Vascular Diseases; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Endocrine System Diseases; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases

Central Study Contacts

Sara BARRAUD, Dr.

CONTACT

03.10.73.63.82; sbarraud@chu-reims.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 10, 2024
• First Posted: June 13, 2024
• Study Start: January 25, 2023
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: June 13, 2024

Record last verified: 2024-06

Locations

FR (1)