Epidemiological Insights Into the Formation, Progression, and Rupture of Intracranial Aneurysms: A Retrospective, Multi-Center Hospital-Based Study in China

NCT06456814 | Recruiting

• 1 other identifier: NCT20240606IA
• Study Type: observational
• Target: 30,000
• Locations: 1 country
• Sites: 1

Brief Summary

This is a retrospective, hospital-based and multi-center study aiming at investigating the potential exposures associated with the formation, progression, and rupture of intracranial aneurysms in Chinese population.

Conditions

Intracranial Aneurysm; Subarachnoid Hemorrhage, Aneurysmal; Cerebral Aneurysm; Brain Aneurysm

Keywords

Intracranial aneurysm; Clinical epidemiology; Exposures

Outcome Measures

Primary Outcomes (1)

• Intracranial aneurysm

  The presence or absence of IAs detected by digital subtractive angiography or by cranial computed tomography angiography / magnetic resonance angiography.

  2010.01.01-2024.06.01

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population underwent cerebrovascular examinations, with the majority conducted in clinical settings and the minority for health screening purposes, sourced from real-world electronic medical record databases.

You may qualify if:

• Aged ≥ 18 and ≤ 18 years old;
• With complete demographic data including age and sex;
• With medical record archiving officially.

You may not qualify if:

• Missing data of age, sex or hypertensive status;
• Age \<18 or \>80 years;
• Pregnancy;
• With a history of intracranial arteriovenous malformation, Moyamoya, polycystic kidney disease, Ehlers-Danlos syndrome, Gronblad-Strandberg syndrome, or Marfan syndrome;
• Suspicion for dissecting or mycotic aneurysms or aneurysm-like lesions that were indistinguishable from the infundibulum, fenestration, dilation, or atherosclerotic remodeling on structural imaging scans.

Sponsors & Collaborators

• Zhujiang Hospital: lead
• Beijing Tiantan Hospital: collaborator
• Guangdong Provincial People's Hospital: collaborator
• First Affiliated Hospital of Chongqing Medical University: collaborator
• The Affiliated Hospital Of Southwest Medical University: collaborator

Study Sites (1)

Zhujiang Hospital

Guangzhou, China

RECRUITING

Related Publications (1)

• Lin J, Feng X, Wen Z, Huang C, Huang M, Huang J, Ge R, Xu A, Ma G, Shi H, Hu Y, Yuan H, Li C, Yi R, Jin Y, Liang S, Zhang X, Li X, Duan C. Association between triglyceride-glucose index and intracranial aneurysm rupture: findings from a retrospective study. Neurosurg Rev. 2025 Jun 21;48(1):521. doi: 10.1007/s10143-025-03680-1.

  PMID: 40542179 DERIVED

MeSH Terms

Conditions

Intracranial Aneurysm; Subarachnoid Hemorrhage

Condition Hierarchy (Ancestors)

Intracranial Arterial Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Intracranial Hemorrhages; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Chuanzhi Duan, MD, PhD

CONTACT

15622311746; doctor_duanzj@163.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief physican; Professor

Study Record Dates

• First Submitted: June 7, 2024
• First Posted: June 13, 2024
• Study Start: January 1, 2010
• Primary Completion: June 1, 2024
• Study Completion (Estimated): December 31, 2026
• Last Updated: June 13, 2024

Record last verified: 2024-06

Locations

CN (1)