Screening Intracranial Aneurysms With Magnetic Resonance Angiography (MRA) in China
Epidemiology of Cerebral Aneurysms With MRA in China in Middle-aged or Elder Person: a Population-based Survey
2 other identifiers
observational
4,500
1 country
1
Brief Summary
The Chinese Cerebral Aneurysms Survey is a continuing prospective study among middle-aged and older individuals (35 - 75 years) that aims to determine the prevalence of cerebral intracranial aneurysms in the general population with MRA at 3.0 Tesla (T).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2007
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2008
CompletedFirst Submitted
Initial submission to the registry
June 19, 2009
CompletedFirst Posted
Study publicly available on registry
June 23, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2010
CompletedDecember 14, 2009
December 1, 2009
1.5 years
June 19, 2009
December 11, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Cerebral intracranial aneurysms identified by 3-D TOF-MRA at 3T
18 months after the study
Secondary Outcomes (1)
Suspected cerebral aneurysms detected by MRA underwent digital subtraction angiography (DSA) examination
32-36 months
Eligibility Criteria
The investigators recruited 4500-5000 native inhabitants aged 35-75 years lived in China according to China census-tract data from the year 2005. The gender was accordance with China census-tract data, and the population aged 35-75 years has a higher incident of intracranial aneurysm in the literature. Assuming an 8 percent prevalence of intracranial aneurysm in the general population and using a two-sided alpha value of 0.05, the investigators estimated that 4500-5000 native inhabitants would need to be enrolled for the study.
You may qualify if:
- Native inhabitants lived in a defined area sites in China
- Aged 35-75 years
You may not qualify if:
- Less than 35 years old or more than 75 years old
- Incompetent patient who cannot give consent for routine MR Angiography and his/her surrogate decision maker is not available
- Any patients with a contraindication to having a standard MRI examination, such as phase maker, orbital metallic foreign body, etc.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, 200233, China
Related Publications (1)
Li MH, Cheng YS, Li YD, Fang C, Chen SW, Wang W, Hu DJ, Xu HW. Large-cohort comparison between three-dimensional time-of-flight magnetic resonance and rotational digital subtraction angiographies in intracranial aneurysm detection. Stroke. 2009 Sep;40(9):3127-9. doi: 10.1161/STROKEAHA.109.553800. Epub 2009 Jun 25.
PMID: 19556531RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Ming-Hua Li, MD, PhD
The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University
- PRINCIPAL INVESTIGATOR
Yong-Dong Li, MD, PhD
The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- ECOLOGIC OR COMMUNITY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
June 19, 2009
First Posted
June 23, 2009
Study Start
June 1, 2007
Primary Completion
December 1, 2008
Study Completion
June 1, 2010
Last Updated
December 14, 2009
Record last verified: 2009-12