Effects of Smoking on Placenta and Lactation

NCT06456645 | Completed DMC

• 1 other identifier: MCBU_Smoking
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

Maternal smoking during pregnancy although it is known to be associated with fetal growth restriction, it's effect on postpartum breastfeeding is not yet clear. The aim of the present study was to examine the impacts of smoking in pregnancy on breastfeeding as well as its impacts on placental immunoreactivity.

Conditions

Smoking, Tobacco; Placenta Diseases; Breastfeeding; Fetal Conditions

Keywords

Smoking cigarette; placenta; IGF-1; Leptin; HPL; breastfeeding

Outcome Measures

Primary Outcomes (1)

• 100% Patients's placenta with smoking in Pregnancy and 100% Patients's Placenta with from non-smoking in Pregnancy. Placenta Tissues Staining Measured by immunohistochemistry and biochemistry technique.

  Baseline

Secondary Outcomes (1)

• Sociodemographic, birth history, and breastfeeding questions were measured by survey technique.

  Baseline

Study Arms (2)

Group 1:

Smokers (study group)

Group 2:

Non-Smokers (control group)

Eligibility Criteria

• Age: 18 Years - 45 Years
• Gender Eligibility Details: Pregnant female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women who have started smoking at least 100 cigarettes in her lifetime and who now smokes every day

You may qualify if:

• Pregnant women who have started smoking at least 100 cigarettes in her lifetime and who now smokes every day,
• Pregnant women who have never smoked throughout their life, including pregnancy(16),
• Pregnant women who gave birth at term,
• Multiple pregnancy, preeclampsia, gestational diabetes, thyroid dysfunction, those who do not have a systemic disease and due to systemic disease during pregnancy those who do not use
• Pregnant women who had spontaneous vaginal delivery,
• In order not to encounter communication barriers and because cultural differences may vary, the pregnant woman is not a foreign national,
• Pregnant women who do not have any barriers to communication by phone,
• Those who do not have any health problems that prevent breastfeeding

You may not qualify if:

• multiple pregnancy
• insulin dependent diabetes
• pregnant women who have had a cesarean section
• preeclampsia
• thyroid disease

Sponsors & Collaborators

• Celal Bayar University: lead

Study Sites (1)

Manisa Celal Bayar Universitesi

Manisa, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITH DNA

Placenta tissue

MeSH Terms

Conditions

Tobacco Smoking; Placenta Diseases; Breast Feeding; Cigarette Smoking

Condition Hierarchy (Ancestors)

Smoking; Behavior; Tobacco Use; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Feeding Behavior

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 29, 2024
• First Posted: June 13, 2024
• Study Start: May 1, 2017
• Primary Completion: June 17, 2019
• Study Completion: November 5, 2019
• Last Updated: June 13, 2024

Record last verified: 2024-06

Locations

TU (1)