Efficacy of Pure Honey Dressing in Contrast to Alvogyl in the Resolution of Dry Socket

NCT06456060 | Recruiting Phase 1 DMC

• 1 other identifier: 639/NID/24
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Dry socket, or Alveolar Osteitis, is the most common complication that can follow a tooth extraction. Over the years, various approaches have been employed to expedite the healing process and alleviate the associated symptoms. Among these, Alvogyl has been the most commonly used dry socket dressing all over the globe. However due to Alvogyl's potential side effect of causing a foreign body reaction \& ultimately necrosis of the alveolar bone if left in the socket along with its high cost, scientists have sought to develop new techniques. Among them, Honey dressing has heralded promising properties in facilitating the resolution of dry socket, thus opening the window of a side-effect free natural viable alternative to Alvogyl. In this research, we aim to compare the efficacy of pure Honey as a dry socket dressing in comparison to Alvogyl.

Conditions

Dry Socket

Outcome Measures

Primary Outcomes (1)

• Pain relief

  The patients will be requested to note daily pain records on a (0-10) visual analog scale, with 0 representing no pain and 10 representing the worst pain..

  Patients will be reviewed at 5 min post-medication, 30 min post-medication, 60 min post-medication, 2nd day post-medication, 4th day post-medication and 7th day post-medication.

Study Arms (2)

Control (Alvogyl) Group

ACTIVE COMPARATOR

In Control Group, after flushing the socket with normal saline a gauze soaked with Alvogyl will be used to cover the socket..

Drug: Alvogyl

Study (Honey) Group

EXPERIMENTAL

In the Study (Honey) Group, after flushing the socket with normal saline, 2 ml of Honey soaked in a sterile gauze will be applied to cover the socket.

Drug: Honey

Interventions

Alvogyl DRUG

Alvogyl soaked in a sterile gauze will be applied to cover the socket.

Control (Alvogyl) Group

Honey DRUG

Honey soaked in a sterile gauze will be applied to cover the socket.

Study (Honey) Group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients over 18 years of age of both genders.
• Patients who underwent extraction of teeth and were clinically diagnosed with dry socket at the OMFS department of NID, Multan.
• Patients which give informed consent.

You may not qualify if:

• Patients below the age of 18 and above the age of 70.
• Patients with various bone diseases, including osteoporosis \& a history of taking oral or intravenous bisphosphonates
• Patients with a history of radiotherapy on the head, neck, and jawbones were excluded from this study,
• Patients with systemic diseases such as diabetes mellitus, hepatic dysfunctions, blood dyscrasias, and bleeding disorders
• Patients with allergy to Ibuprofen \& honey
• Patients having symptoms similar to dry socket due to retained root pieces, oroantral communication, or any bony or soft tissue pathology by the help of a radiograph
• Patients who did not give informed consent.

Sponsors & Collaborators

• Watim Medical & Dental College: lead

Study Sites (1)

Nishtar Institute of Dentistry

Multan Khurd, Punjab Province, Pakistan

RECRUITING

Related Publications (3)

• Keshini MP, Shetty SK, Sundar S, Chandan SN, Manjula S. Assessment of Healing Using Alvogyl and Platelet Rich Fibrin in Patients with Dry Socket - An Evaluative Study. Ann Maxillofac Surg. 2020 Jul-Dec;10(2):320-324. doi: 10.4103/ams.ams_259_19. Epub 2020 Dec 23.

  PMID: 33708574 RESULT

• Abu-Mostafa N, Al-Daghamin S, Al-Anazi A, Al-Jumaah N, Alnesafi A. The influence of intra-alveolar application of honey versus Chlorhexidine rinse on the incidence of Alveolar Osteitis following molar teeth extraction. A randomized clinical parallel trial. J Clin Exp Dent. 2019 Oct 1;11(10):e871-e876. doi: 10.4317/jced.55743. eCollection 2019 Oct.

  PMID: 31636855 RESULT

• Soni N, Singh V, Mohammad S, Singh RK, Pal US, Singh R, Aggrwal J, Pal M. Effects of honey in the management of alveolar osteitis: A study. Natl J Maxillofac Surg. 2016 Jul-Dec;7(2):136-147. doi: 10.4103/0975-5950.201354.

  PMID: 28356684 RESULT

MeSH Terms

Conditions

Dry Socket

Interventions

butyl aminobenzoate, eugenol, iodoform, spearmint oil drug combinations; Honey

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Muhammad Ilyas, MBBS, FCPS

  Watim Medical & Dental College

  STUDY DIRECTOR

Central Study Contacts

Muhammad Raif Ilyas, BDS, FCPS -1

CONTACT

00923319268801; raifilyas@gmail.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants will be blinded about the use of honey or Alveogyl in the dressing.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Patients will be divided into the following two groups: 1. Study group 2. Control group In the study group, after flushing the socket with normal saline, 2 ml of Honey soaked in a sterile gauze will be applied to cover the socket, whereas in the control group, a gauze with Alveogyl will be used to cover the socket instead of Honey.

Study Record Dates

• First Submitted: June 6, 2024
• First Posted: June 13, 2024
• Study Start: June 1, 2024
• Primary Completion: December 30, 2024
• Study Completion: January 30, 2025
• Last Updated: July 23, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)