SUPPLEMENTARY EFFECTS OF RESISTANCE TRAINING IN ADDITION TO JOINT MOBILIZATION IN PERSONS WITH KNEE OSTEOARTHRITIS

NCT06444932 | Enrolling By Invitation

• 1 other identifier: FUI/CTR/2024/12
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Joint mobilization and resistance exercise training are effective conservative treatment options for the management of osteoarthritis. However, currently no study has highlighted the supplementary effects of resistance training in addition to joint mobilization in people suffering from knee osteoarthritis. The current study is aimed at bridging the gap in literature and providing evidence regarding the additive impact of resistance training to joint mobilization in knee osteoarthritis.

Conditions

Knee Osteoarthritis

Outcome Measures

Primary Outcomes (8)

• Walking related performance fatigability

  Walking related performance fatigability will be measured using 6 minute walk test. Greater fatigability indicates poorer outcome.

  4 weeks

• Stride Length

  Gait analysis will be done to analyze stride length. A greater stride length signifies positive outcome and prognosis.

  4 weeks

• Gait velocity

  Gait analysis will be done to analyze gaot velocity. A greater gait velocity signifies positive outcome and prognosis.

  4 weeks

• Knee Pain

  Knee Pain will be measured using visual analogue scale (VAS) from 0-100mm. A higher score on VAS indicated greater pain.

  4 weeks

• Knee range of motion

  Knee range of motion will be measured using a goniometer. A higher ROM signifies positive outcome.

  4 weeks

• Functional Disability

  Knee functional disability will be assessed using Knee Osteoarthritis and Outcome Score (KOOS) with a score ranging from 0-100. A lower score on KOOS signifies greater functional disability.

  4 weeks

• Isometric Muscle Strength

  Isometric Muscle Strength will be quantified using dynamometer. A higher score on dynamometer signifies greater muscle strength and good prognosis.

  4 weeks

• Functional capacity

  5 repetition sit to stand test will be used to determine knee related functional capacity, which will be quantified in terms of time. A smaller time will denote greater functional capacity.

  4 weeks

Study Arms (2)

Active Comparator

ACTIVE COMPARATOR

Procedure: Joint Mobilization; Device: Transcutaneous Electric Nerve Stimulation (TENS); Device: Heating Pad

Experimental Group

EXPERIMENTAL

Procedure: Joint Mobilization; Procedure: Resistance Exercise Training; Device: Transcutaneous Electric Nerve Stimulation (TENS); Device: Heating Pad

Interventions

Joint Mobilization PROCEDURE

Patellofemoral and tibiofemoral joint mobilization

Active Comparator; Experimental Group

Resistance Exercise Training PROCEDURE

Lower limb resistance exercise training

Experimental Group

Transcutaneous Electric Nerve Stimulation (TENS) DEVICE

Transcutaneous Electric Nerve Stimulation (TENS)

Active Comparator; Experimental Group

Heating Pad DEVICE

Heating pad for heat therapy

Active Comparator; Experimental Group

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Knee OA grade I-III
• Individuals of either gender aged 40-70 years
• Knee OA history of no less than 3 months
• Knee pain no more than 8/10 cm on the visual analogue scale (VAS)
• Radiological evidence of grade III or less on Kellgren classification.

You may not qualify if:

• Those with signs of serious pathology such as malignancy, inflammatory disorder or infection.
• History of trauma or fractures in lower extremity
• Signs of lumbar radiculopathy or myelopathy
• History of knee surgery or replacement and/or receiving intra-articular steroid therapy in the preceding two months

Sponsors & Collaborators

• Foundation University Islamabad: lead

Study Sites (1)

Foundation Univeristy Islamabad

Islamabad, Pakistan

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Resistance Training; Transcutaneous Electric Nerve Stimulation

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Electric Stimulation Therapy; Analgesia; Anesthesia and Analgesia

Study Officials

• Wania Maheen, DPT

  Foundation University Islamabad

  PRINCIPAL INVESTIGATOR

• Muhammad Osama, PhD*

  Foundation University Islamabad

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Double arm parallel design RCT

Study Record Dates

• First Submitted: May 27, 2024
• First Posted: June 6, 2024
• Study Start: June 10, 2024
• Primary Completion: December 10, 2024
• Study Completion: December 30, 2024
• Last Updated: June 6, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)