Study on Therapeutic Mechanism of Natural Psychotherapy for Neurosis

NCT06443125 | Recruiting DMC

• 1 other identifier: CASPsy6
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 2

Brief Summary

explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder

Conditions

Obsessive-Compulsive Disorder

Keywords

obsessive-compulsive disorder; natural psychotherapy

Outcome Measures

Primary Outcomes (6)

• Obsessive-compulsive symptoms

  Obsessive-compulsive symptoms were assessed according to the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), The total score ranges from 0 to 40, with higher scores indicating more severe symptoms.

  Baseline, 12 weeks

• Cognitive function

  Cognitive inhibition was assessed using the emotional color-word Stroop task. The emotional Stroop task is a type of being Widely used cognitive inhibition assessment tools. The longer the reaction time, the worse the cognitive inhibition ability.

  Baseline, 12 weeks

• Mood and behavior

  Mood changes judged using gait and face recognition

  Baseline, 12 weeks

• ERP components associated with cognitive function

  To explore the ERP component analysis related to cognitive inhibition and Behavioral inhibition in obsessive-compulsive disorder (OCD) by event related potential (ERP) analysis

  Baseline, 12 weeks

• rest fMRI in Obsessive-compulsive patients

  The changes of resting-state functional connectivity were analyzed in patients with OCD before and after intervention. Resting-state functional connectivity：FC(Functional connectivity). Resting-state functional brain imaging data were collected using a GE 3.0T magnetic resonance scanner (GE Discovery MR750) at the Brain Imaging Center, Institute of Psychology, Chinese Academy of Sciences.

  Baseline, 12 weeks

• Behavioral inhibition

  behavioral inhibition was assessed using the emotional stop signal task (SST). The emotional SST task is a type of being Widely used behavioral inhibition assessment tools. Among them, the greater the SSRT, the worse the behavioral inhibition ability.

  Baseline, 12 weeks

Study Arms (1)

Natural Psychotherapy intervention for obsessive-compulsive disorder

EXPERIMENTAL

Inpatient naturopathic treatment was performed once a day for 45 consecutive days

Other: Natural psychotherapy

Interventions

Natural psychotherapy OTHER

Draw ideas from traditional Chinese culture, learn from the practice of Morita therapy in Japan, and create local practice experience. At the same time, a variety of research methods such as cognitive assessment and brain imaging were used to establish the scientific, professional and objective evaluation indexes of the therapy.

Natural Psychotherapy intervention for obsessive-compulsive disorder

Eligibility Criteria

• Age: 15 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Have a diagnosis of obsessive-compulsive disorder or compulsive behavior
• Duration of symptoms for not less than 12 months
• Age 15-60 years old.
• You can participate in the whole experiment and offline assessment in Beijing

You may not qualify if:

• Documented disease of physical diseases including, but not limited to stroke, tumor, Parkinson's disease, Huntington's disease, seizure, epilepsy, history of brain trauma
• Subjects who suffered from alcohol or illegal drug abuse/dependence

Sponsors & Collaborators

• Xiang Yang Zhang: lead

Study Sites (2)

Anhui Mental Health Center

Hefei, Anhui, 230022, China

RECRUITING

Institute of Psychology, Chinese Academy of Sciences

Beijing, China

RECRUITING

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders

Study Officials

• Xiang-Yang Zhang, M.D., Ph.D

  Institute of Psychology, Chinese Academy of Science

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Zhang Y Xiang, M.D., Ph.D

CONTACT

+86-10-62710644; zhangxy@psych.ac.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 26, 2023
• First Posted: June 5, 2024
• Study Start: August 1, 2023
• Primary Completion: August 1, 2025
• Study Completion: August 1, 2025
• Last Updated: December 27, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

CN (2)