Unique Electroencephalography (EEG) Markers of Habit Behaviors in Obsessive-Compulsive Disorder (OCD)

NCT06882902 | Enrolling By Invitation

• 1 other identifier: SMHC-OCD-010
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

This study focuses on explaining the occurrence and development of compulsive behaviors from habit hypothesis. Investigators will study both OCD patients and healthy individuals using Hardwick's forced-response time task(2019), the habit Go/No-Go task, and the Intra-Extra Dimensional Set Shift task. Investigators aim to explore the cognitive abilities and differences between OCD patients and healthy controls in these three tasks. Control variables will include participants' levels of anxiety, depression, and stress, as well as sense of incompleteness and intolerance of uncertainty levels. By examining the differences in habit formation and expression abilities between OCD patients and healthy controls, and exploring the specific brain electroencephalographic activity processes in OCD patients, investigators hope to reveal the abnormal neural activity in habit-related circuits in OCD patients. This could provide new insights for the diagnosis and treatment of OCD.

Conditions

Obsessive-Compulsive Disorder

Keywords

habit; cognitive flexibility; response inhibition

Outcome Measures

Primary Outcomes (1)

• Reduction of Y-BOCS scores

  We defined the habit training response as the percent reduction of Y-BOCS scores greater than or equal to 35%.

  baseline#after- intervention#1 weeks# (pre-intervention, after intervention, one weeks after intervention)

Study Arms (1)

Habit formation

EXPERIMENTAL

Behavioral: habit formation training

Interventions

habit formation training BEHAVIORAL

Participants need to perform habit formation exercises for 4 consecutive days. During the exercises, participants will see a picture stimulus and need to learn the corresponding key press. Each day, participants will spend 30 minutes on the training.

Habit formation

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged between 18 and 50;
• Y-BOCS score greater than or equal to 16;
• Meet DSM-5 diagnostic criteria with no medication changes in the past two weeks;
• Right-handed.

You may not qualify if:

• Diagnosed with any DSM-5 disorder other than OCD;
• Have a major physical illness;
• Have strong suicidal ideation.

Sponsors & Collaborators

• Shanghai Mental Health Center: lead

Study Sites (1)

Shanghai Mental Health Center

Shanghai, Shanghai Municipality, 200030, China

Location

MeSH Terms

Conditions

Obsessive-Compulsive Disorder; Habits

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 29, 2024
• First Posted: March 19, 2025
• Study Start: May 5, 2024
• Primary Completion: April 30, 2025
• Study Completion: July 30, 2025
• Last Updated: May 28, 2025

Record last verified: 2025-04

Locations

CN (1)