Exercise Prehabilitation for Locoregional Esophageal Cancer
1 other identifier
interventional
20
1 country
1
Brief Summary
The purpose of the study is to examine the feasibility and acceptability of exercise "prehabilitation" for patients preparing for esophageal cancer resection (removal).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2024
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 21, 2024
CompletedStudy Start
First participant enrolled
May 21, 2024
CompletedFirst Posted
Study publicly available on registry
May 28, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 1, 2027
December 4, 2025
December 1, 2025
2.9 years
May 21, 2024
December 3, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Retention
The number of participants who complete T0 and T1 measures.
Up to 11 weeks
Secondary Outcomes (2)
Exploratory outcomes and changes
Up to 17 weeks
Clinical and treatment outcomes
Up to 17 weeks
Study Arms (1)
Exercise prehabilitation
EXPERIMENTALIn this trial participants will participate in an exercise program for 5 to 17 weeks, varying with treatment plans. Participants will receive resistance training equipment and participate in resistance training sessions twice per week (approximately 30-45 minutes per session). A Fitbit device will be provided to monitor step counts.
Interventions
Eligibility Criteria
You may qualify if:
- Biopsy-proven locoregional esophageal cancer (LEC)
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Treatment plan including neoadjuvant chemoradiation therapy and surgical resection
- Ability to read and speak English
You may not qualify if:
- Regular engagement in resistance training (2x/week targeting all major muscle groups)
- Screen failure for exercise safety based on PAR-Q
- Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
- Recent fracture or acute musculoskeletal injury that precludes ability to participate in resistance training safely
- Numeric pain rating scale of 7 or more out of 10
- Myopathic or rheumatologic disease that impacts physical function
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Moffitt Cancer Center
Tampa, Florida, 33612, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nathan Parker, PhD
Moffitt Cancer Center
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 21, 2024
First Posted
May 28, 2024
Study Start
May 21, 2024
Primary Completion (Estimated)
May 1, 2027
Study Completion (Estimated)
May 1, 2027
Last Updated
December 4, 2025
Record last verified: 2025-12