Dynamic Whole-body PET/CT Imaging in Clinical Oncology

NCT06424873 | Recruiting

• 1 other identifier: 2023-02102
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times in patient with oncologic pathology . The main question\[s\] it aims to answer are:

• \[question 1\]
• \[question 2\] Participants will \[describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items\].

Conditions

Cancer

Outcome Measures

Primary Outcomes (1)

• Standard SUV measurement metric

  The standard SUV measurement metric will be compared with the measured influx rate Ki as obtained from dynamic PET/CT imaging for FDG-avid processes. We expect a correlation coefficient of at least 0.8.

  through study completion , an average of 2 years

Secondary Outcomes (2)

• Image quality

  through study completion , an average of 2 years

• Certainty in diagnosis of FDG-avid processes

  through study completion , an average of 2 years

Study Arms (1)

One arm study

EXPERIMENTAL

Additionnal images during PET/CT

Radiation: PET/CT with FDG or FES

Interventions

PET/CT with FDG or FES RADIATION

The study consists of an additional 50 minutes of imaging during the radiotracer's uptake phase prior to their clinical scan (standard of care).

One arm study

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients clinically indicated for whole-body PET evaluation.
• Patient must agree to lie still in the camera.
• Patient must be able to comply with study procedures.
• Patient must be able to provide informed consent.

You may not qualify if:

• Patients \< 18 years of age.
• Pregnant women are excluded.

Sponsors & Collaborators

• Valentina Garibotto: lead

Study Sites (1)

Geneva University Hospitals

Geneva, 1205, Switzerland

RECRUITING

MeSH Terms

Conditions

Neoplasms

Interventions

Fluorodeoxyglucose F18; proto-oncogene protein c-fes-fps

Intervention Hierarchy (Ancestors)

Deoxyglucose; Deoxy Sugars; Carbohydrates

Central Study Contacts

Valentina Garibotto, Pr

CONTACT

+41223727252; valentina.garibotto@hcuge.ch

Ismini Mainta, Dr

CONTACT

+41795534454; IsminiCharis.Mainta@hcuge.ch

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Head of the Division of Nuclear Medicine and Molecular imaging

Model Details: PET/CT

Study Record Dates

• First Submitted: November 9, 2023
• First Posted: May 22, 2024
• Study Start: April 1, 2024
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: May 22, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)