NCT06412523

Brief Summary

Resistant microorganisms are public health problems because they affect the treatment of infectious diseases and the survival of patients. Neurosurgical procedures with placement of intracranial pressure monitoring and external ventricular drainage devices are related to increased morbidity and mortality. In Brazil, there are several multicenter studies demonstrating the prevalence and types of resistant microorganisms, however, there is a lack of data related to central nervous system infections associated with invasive devices, which can have a direct impact on prevention and treatment policies.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
554

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2022

Geographic Reach
1 country

18 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 11, 2022

Completed
4 days until next milestone

Study Start

First participant enrolled

August 15, 2022

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2023

Completed
6 months until next milestone

First Posted

Study publicly available on registry

May 14, 2024

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2024

Completed
Last Updated

May 14, 2024

Status Verified

May 1, 2024

Enrollment Period

1.3 years

First QC Date

August 11, 2022

Last Update Submit

May 8, 2024

Conditions

Keywords

Central Nervous System InfectionsCatheters

Outcome Measures

Primary Outcomes (1)

  • Incidence density of central nervous system infection

    Incidence density will be reported as number of CNS infections per 1000 catheters/day, together with 95% CI. Cumulative incidence will also be reported.

    30 days after study inclusion

Secondary Outcomes (6)

  • Microbiological characteristics

    30 days after study inclusion

  • Risk factors

    30 days after study inclusion

  • Treatment

    30 days after study inclusion

  • Costs

    30 days after study inclusion

  • Deaths

    30 days and 6 months after study inclusion

  • +1 more secondary outcomes

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Adults admitted to Intensive Care Units.

You may qualify if:

  • All patients over 18 years of age admitted to the ICU in the selected hospitals during the study period, using intracranial pressure monitoring catheters and/or external ventricular shunt.

You may not qualify if:

  • Diagnosis of brain death.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (18)

Unimed Vitória

Vitória, Espírito Santo, Brazil

Location

Hospital Geral Cleriston Andrade

Feira de Santana, Estado de Bahia, Brazil

Location

Hospital da Cidade

Salvador, Estado de Bahia, Brazil

Location

Santa Casa de Belo Horizonte

Belo Horizonte, Minas Gerais, Brazil

Location

Santa Casa de Misericórdia de Passos

Passos, Minas Gerais, Brazil

Location

Santa Casa de Misericórdia de São João del Rei

São João del Rei, Minas Gerais, Brazil

Location

Instituto Estadual do Cérebro Paulo Niemeyer (Pró Saúde- Associação Beneficente de Assistência Social e Hospitalar)

Rio de Janeiro, Rio de Janeiro, Brazil

Location

Hospital Universitário Onofre Lopes

Natal, Rio Grande do Norte, Brazil

Location

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Location

Instituto Baía Sul de Ensino e Pesquisa Irineu May Brodbeck

Florianópolis, Santa Catarina, Brazil

Location

Hospital de Amor (Fundação PIO XII - Barretos)

Barretos, São Paulo, Brazil

Location

Hospital Unimed Limeira

Limeira, São Paulo, Brazil

Location

Hospital das Clínicas - FMUSP Ribeirão Preto

Ribeirão Preto, São Paulo, Brazil

Location

Hospital e Maternidade Brasil (Rede D´or São Luis)

Santo André, São Paulo, Brazil

Location

Beneficência Portuguesa de São Paulo

São Paulo, São Paulo, Brazil

Location

Hospital do Coração

São Paulo, São Paulo, Brazil

Location

Hospital São Luiz Itaim

São Paulo, São Paulo, Brazil

Location

Hospital São Paulo

São Paulo, São Paulo, Brazil

Location

MeSH Terms

Conditions

Central Nervous System Infections

Condition Hierarchy (Ancestors)

InfectionsCentral Nervous System DiseasesNervous System Diseases

Study Officials

  • Viviane Veiga, PhD

    Beneficencia Portuguesa Sao Paulo

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

August 11, 2022

First Posted

May 14, 2024

Study Start

August 15, 2022

Primary Completion

December 1, 2023

Study Completion

June 30, 2024

Last Updated

May 14, 2024

Record last verified: 2024-05

Locations