Central Nervous System Disorders Following Hematopoietic Stem Cell Transplantation

Primary Outcomes (4)

• Clinical characteristics of infectious and non-infectious CNS disorders following allogeneic or autologous HSCT

  Clinical characteristics to be analysed: * Recipient/donor sex * Recipient/donor age (at HSCT) * Primary diagnosis * Status of the primary disease at the time of HSCT - remission (partial or complete) /relapse /relapse including CNS involvement/progression, stable disease, unknown) * Prior CNS radiotherapy * Prior intrathecal (antineoplastic) treatment * Prior (antineoplastic) treatment (especially 'novel drugs´) * Pre-existing medical conditions * Recipient/donor serostatus of CMV, EBV, HHV-6, HSV, VZV, Toxoplasma spp. * Type of transplant (allogeneic vs. autologous) * Type of donor (MRD vs. haploidentical donor vs. other donor type) * Stem cell source (CB vs. BM vs. PB) * Type of conditioning (RIC vs MAC) * TCD (yes vs. no), ATG (yes vs. no), alemtuzumab (yes vs. no) * Acute and chronic GvHD (at day 0, including grade) * ECOG performance status at different time points * Concomitant infections * Selected peripheral blood parameters

  32 months

• Diagnostic characteristics of infectious and non-infectious CNS disorders following allogeneic or autologous HSCT

  Diagnostic characteristics analyzed: * Recipient´s age at onset of the CNS disorder (day 0) * Date of symptom onset of the CNS disorder * Type of symptoms (e.g. seizures, hemiplegia, paraplegia, paresis, psychosis, vomiting, confusion/altered consciousness, fever) * Date of diagnosis of the CNS disorder (e.g. CSF analysis) * Clinical diagnosis of CNS infection (e.g. encephalitis, meningitis, meningoencephalitis, myelitis, abscess, leukoencephalopathy) * Clinical diagnosis of non-infectious CNS disorder (e.g. metabolic/drug-induced disorder, posterior reversible encephalopathy syndrome, bleeding, thrombosis, ischemic stroke, CNS relapse of a underlying malignancy) * Time interval between HSCT and symptom onset * Time interval between symptom onset and diagnosis * Antimicrobial prophylaxis prior to onset of CNS disorder * Level of likelihood of the type of CNS disorder:

Conditions