Monitoring of Non-Surgical Treatment of Peri-implantitis

NCT06408467 | Completed

• 1 other identifier: Lahanna
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to investigate the response to non-surgical treatment of peri-implantitis diseases during the maintenance phase. The patients underwent non-surgical implant maintenance treatment, and the success of the treatment was measured again after 30 days using the same criteria and methods.

Conditions

Peri-implant Mucositis; Peri-Implantitis

Keywords

peri-implant treatment; aMMP-8; non-surgical treatment

Outcome Measures

Primary Outcomes (3)

• the result of the participants who were measured aMMP-8

  Measure aMMP-8-level ng/ml

  1 month

• the result of the participants who were measured BOP

  measure bleeding on probing in PISF

  1 month

• the result of the participants who were measured PPD

  measure peri-implant pocket depth

  1 month

Study Arms (1)

The effect and monitoring of maintenance therapy for peri-implantitis

EXPERIMENTAL

Other: aMMP-8 diagnostic test

Interventions

aMMP-8 diagnostic test OTHER

40 patients

The effect and monitoring of maintenance therapy for peri-implantitis

Eligibility Criteria

• Age: 25 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• implant patients arriving for a maintenance visit at a dental clinic
• a diagnosis of peri-implant healthy, peri-implant mucositis, or peri-implantitis by a dentist
• a written informed consent.

You may not qualify if:

• Smoking
• age under 25
• antibiotic treatment within six months
• the maintenance treatment had been completed within 6 months.

Sponsors & Collaborators

• Lahanna oy: lead
• University of Helsinki: collaborator

Study Sites (1)

University of Helsinki

Helsinki, 00029, Finland

Location

Related Publications (5)

• Lindhe J, Meyle J; Group D of European Workshop on Periodontology. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008 Sep;35(8 Suppl):282-5. doi: 10.1111/j.1600-051X.2008.01283.x.

  PMID: 18724855 RESULT

• Figuero E, Graziani F, Sanz I, Herrera D, Sanz M. Management of peri-implant mucositis and peri-implantitis. Periodontol 2000. 2014 Oct;66(1):255-73. doi: 10.1111/prd.12049.

  PMID: 25123773 RESULT

• Lahteenmaki H, Umeizudike KA, Heikkinen AM, Raisanen IT, Rathnayake N, Johannsen G, Tervahartiala T, Nwhator SO, Sorsa T. aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting. Diagnostics (Basel). 2020 Aug 5;10(8):562. doi: 10.3390/diagnostics10080562.

  PMID: 32764436 RESULT

• Alassy H, Parachuru P, Wolff L. Peri-Implantitis Diagnosis and Prognosis Using Biomarkers in Peri-Implant Crevicular Fluid: A Narrative Review. Diagnostics (Basel). 2019 Dec 7;9(4):214. doi: 10.3390/diagnostics9040214.

  PMID: 31817894 RESULT

• Lahteenmaki H, Raisanen IT, Tervahartiala T, Parnanen P, Patila T, Sorsa T. Monitoring of Nonsurgical Treatment of Peri-Implantitis Traditional Measurement Methods and aMMP-8 Test Technology: A Pilot Study. Int J Dent. 2025 Nov 27;2025:6681032. doi: 10.1155/ijod/6681032. eCollection 2025.

  PMID: 41358008 DERIVED

MeSH Terms

Conditions

Peri-Implantitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Timo Sorsa, Professor

  University of Helsinki

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 2, 2024
• First Posted: May 10, 2024
• Study Start: January 1, 2022
• Primary Completion: July 1, 2022
• Study Completion: November 15, 2022
• Last Updated: May 10, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR
• Time Frame: starting in June 2025 and end of January 2026
• Access Criteria: information can be shared with an email request to share IPD and other support information. Requests are reviewed with the research team.

Locations

FI (1)