Teh Effect of Subgingival Irrigation Wif Ketorolac and Chlorhexidine in Patients Wif Chronic Periodontist

NCT03836781 | Completed Phase 2 DMC

• 1 other identifier: 2037
• Study Type: interventional
• Target: 2
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, 40 patients with a history of Mild- Periodontitis who were diagnosed with clinical and radiographic findings showed that all of the periodontal parameters before the treatment, during the treatment period Then, scaling \& Root planing and oral hygiene instructions were given to the patients, and after 2 weeks, the patients who received the study were randomly divided into two groups (Balanced Block Randomization) with four blocks according to the visit time. To group A, oral chlorohexidine and to B group, the drug Ketorolac was given. 5 mm of the drugs required every 15 days the areas underwent a gingival wash with an insulin syringe, which lasted for 3 months.

Conditions

Chronic Periodontitis

Outcome Measures

Primary Outcomes (1)

• Pocket depth

  Clinical periodontal measurements to Williams periodontal probe

  3 month

Study Arms (2)

ketorolac 3%

ACTIVE COMPARATOR

ketorolac 3% topical subgingival irrigation was put into the periodontal pocket using an insulin syringe

Drug: Ketorolac

chlorhexidine 2%

OTHER

chlorhexidine 2% topical subgingival irrigation was put into the periodontal pocket using an insulin syringe

Drug: Chlorhexidine 2%

Interventions

Ketorolac DRUG

Ketorolac 3% topical subgingival irrigation was put into the periodontal pocket using an insulin syringe

Also known as: Group A

ketorolac 3%

Chlorhexidine 2% DRUG

Chlorhexidine 2% topical subgingival irrigation was put into the periodontal pocket using an insulin syringe

Also known as: Group B

chlorhexidine 2%

Eligibility Criteria

• Age: 30 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• patients with periodontitis chronic and has a 2 molar symmetrically in the lower jaw pockets of the periodontal depth of at least 5 mm and CAL 1-2 mm in at least one of the surfaces of the teeth, were selected

You may not qualify if:

• systemic disease
• pregnancy or breastfeeding
• allergy drug used
• smoking
• medication 6. not willing to consent to participate in the study
• Trismus 8-The type of disease periodontal (Aggressive) 9. History of periodontal treatment in the previous 6 months 10-orthodontic treatment

Sponsors & Collaborators

• Amirhossein Farahmand: lead

Study Sites (1)

Amirhossein Farahmand

Tehran, 19, Iran

Location

MeSH Terms

Conditions

Chronic Periodontitis

Interventions

Ketorolac

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Indomethacin; Indoles; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: assistant prof

Model Details: split mouth

Study Record Dates

• First Submitted: February 8, 2019
• First Posted: February 11, 2019
• Study Start: April 10, 2018
• Primary Completion: June 8, 2019
• Study Completion: June 15, 2019
• Last Updated: July 5, 2019

Record last verified: 2019-07

Data Sharing

• IPD Sharing: Will not share

Locations

IR (1)