Frequency-time Analysis of Pathological Lung Sounds: Detection and Quantification of Pathological Sounds in Patients With Cystic Fibrosis, Pulmonary Fibrosis or COPD (Chronic Obstructive Pulmonary Disease)

NCT06399094 | Terminated

• 1 other identifier: GHRMSA 1315
• Study Type: observational
• Target: 23
• Locations: 1 country
• Sites: 2

Brief Summary

The main objective of the study is to assess the potential of time-frequency representation and analysis of pulmonary sounds collected with an electronic stethoscope, as part of the routine monitoring of patients with cystic fibrosis, COPD or pulmonary fibrosis.

Conditions

Pulmonary Fibrosis; Chronic Obstructive Pulmonary Disease; Cystic Fibrosis

Outcome Measures

Primary Outcomes (1)

• Lung sounds visible in their representation as time-frequency images

  Pulmonary sounds will be recorded with an electronic stethoscope at each scheduled visit and processed with artificial intelligence using a supervised learning method.

  At inclusion

Secondary Outcomes (1)

• Classification of sounds by severity

  At inclusion

Study Arms (3)

Pulmonary fibrosis

Other: Lung sound recordings

Chronic Obstructive Pulmonary Disease

Other: Lung sound recordings

Cystic fibrosis

Other: Lung sound recordings

Interventions

Lung sound recordings OTHER

The lung sound recordings will be made during a consultation scheduled as part of the patient's usual follow-up, after obtaining the patient's non-opposition.

Chronic Obstructive Pulmonary Disease; Cystic fibrosis; Pulmonary fibrosis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Eligible patients will be recruited during a consultation scheduled as part of the usual follow-up of their pathology in the pneumology department of mulhouse hospital center and strasbourg university hospital center.

You may qualify if:

• Age ≥ 18 years
• Suffering from one of the following pathologies: cystic fibrosis, pulmonary fibrosis, COPD
• Not opposed to participating in the study

You may not qualify if:

• Person under court protection, guardianship or curatorship
• Person deprived of liberty by judicial or administrative decision
• Patient with a history of thoracic surgery, thoracic deformity, heart failure or other relevant illness at the investigator's discretion.

Sponsors & Collaborators

• Groupe Hospitalier de la Region de Mulhouse et Sud Alsace: lead

Study Sites (2)

Hôpitaux Universitaire de Strasbourg

Strasbourg, Bas-Rhin, 67000, France

Location

GHRMSA - Hôpital Emile Muller

Mulhouse, Haut-Rhin, 68100, France

Location

MeSH Terms

Conditions

Pulmonary Fibrosis; Pulmonary Disease, Chronic Obstructive; Cystic Fibrosis

Condition Hierarchy (Ancestors)

Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Lung Diseases, Obstructive; Chronic Disease; Disease Attributes; Pancreatic Diseases; Digestive System Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infant, Newborn, Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 26, 2024
• First Posted: May 3, 2024
• Study Start: July 18, 2024
• Primary Completion: August 30, 2025
• Study Completion: August 30, 2025
• Last Updated: November 17, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)