Microbial Adhesion and Biofilm Formation on Denture Base Materials

NCT06395116 | Active Not Recruiting

• 1 other identifier: R-RP-1-24-3091
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Polymethylmethacrylate (PMMA) has been the material of choice for fabricating complete dentures for more than 80 years now.(1,2) As a material it is easy to handle and can be easily repaired and polished. PMMA while being a low-cost material has good esthetics. Some disadvantages of PMMA as a material are surface roughness and porosities which lead to staining, plaque accumulation and bacterial adhesion over time. Among the various factors that can influence microbial attachment to surfaces, surface roughness, hydrophilicity and free surface energy of PMMA are most important. Carboxylate and methyl ester groups found in PMMA make it a very hydrophilic material with a large amount of free surface energy. Despite the influence of the chemical composition, processing methods play the most important role in developing surface roughness.

Conditions

Inflammatory Response; Microbial Colonization; Denture Stomatitis

Keywords

Microbial adhesion, Biofilm formation, Denture base

Outcome Measures

Primary Outcomes (1)

• Biofilm formation

  such as Candida Albian's and Staphylococcus Aureus colonies per ml

  3 years

Study Arms (3)

Conventionl self cure acrylic group

Constructed from heat cured acrylic resin

Other: Denture base material

3D printed acrylis resin group

Manufactured by additive manufacturing technique

Other: Denture base material

Milled acrylic resin group

Manufactured by milled technique

Other: Denture base material

Interventions

Denture base material OTHER

Denture base material constructed with different techniques for completely edentulous populations

3D printed acrylis resin group; Conventionl self cure acrylic group; Milled acrylic resin group

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Completely edentulous population who attended at the faculty of Dentistry, Menoufia University

You may qualify if:

• Completely edentulous populations.
• Good physical and mental health.
• No systemic disease

You may not qualify if:

• Partially edentulous populations.
• Patients with smoking more than 10 citrates day.
• Patients with systemic diseases.
• Patients undergrown radiotherapy.

Sponsors & Collaborators

• Menoufia University: lead
• Tanta University: collaborator
• Misr University for Science and Technology: collaborator

Study Sites (1)

Mohammed A. El-Sawy

Al Mansurah, 12345, Egypt

Location

MeSH Terms

Conditions

Communicable Diseases; Stomatitis, Denture

Condition Hierarchy (Ancestors)

Infections; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Stomatitis; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Mohammed A. El-Sawy, PhD

  Menoufia University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer, Department of prosthodontics, principle investigator

Study Record Dates

• First Submitted: April 29, 2024
• First Posted: May 1, 2024
• Study Start: January 20, 2023
• Primary Completion: July 4, 2024
• Study Completion: September 5, 2024
• Last Updated: May 1, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)