Neuroinflammation/Oxidative Stress/Cardiac Surgery
NEuOX-postSURg
Assessing Neuroinflammation and Oxidative Stress After Cardiac Surgery: Unveiling Molecular Dynamics and Clinical Outcomes
1 other identifier
observational
60
1 country
1
Brief Summary
The prospective observational study delves into the complex relationship between neuroinflammation and oxidative stress in post-cardiac surgery complications, focusing on postoperative cognitive dysfunction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2024
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 17, 2024
CompletedFirst Posted
Study publicly available on registry
April 30, 2024
CompletedStudy Start
First participant enrolled
April 30, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2025
CompletedApril 30, 2024
April 1, 2024
1 year
April 17, 2024
April 25, 2024
Conditions
Outcome Measures
Primary Outcomes (2)
Number and type of early complications after surgery
Estimating of postoperative complications
1 month
Number and type of postoperative complications
Estimating of postoperative complications
6 months
Secondary Outcomes (4)
Estimating biochemical parameters
1 hour
Estimating biochemical parameters
6 hours
Estimating biochemical parameters Third biochemical examination
1 hour
Estimating biochemical parameters
6 hours
Study Arms (3)
Experimental group 1
Patients scheduled for elective cardiac surgery, such as coronary artery bypass grafting (CABG) or valve replacement, involving extracorporeal circulation (ECC) with a duration less than 60 minutes.
Experimental group 2
Patients undergoing scheduled cardiac procedures, including coronary artery bypass grafting (CABG) or valve replacement, requiring extracorporeal circulation (ECC) for more than 60 minutes.
Control group:
Patients scheduled for cardiac surgical procedures such as coronary artery bypass grafting (CABG) without extracorporeal circulation, and for carotid endarterectomy in neurologically asymptomatic patients prior to the procedure.
Interventions
extracorporeal circulation during cardiosurgical operation
Eligibility Criteria
Patient undergoing cardiac surgery
You may qualify if:
- Undergoing cardiosurgical operation
- Absence of previous neurological disease
- Signed informed consent document
You may not qualify if:
- Presence of neoplasms
- Neurological Disease
- Refusal to participate in the clinical trial
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Europainclinics
Košice, 04011, Slovakia
Related Publications (1)
Kocan L, Sudzina R, Kocanova H, Zavacka M, Pobehova J, Rybar D, Dudova M, Ferencik M, Vaskova J. Early Cognitive Outcomes After Carotid Endarterectomy in Asymptomatic Stenosis: A Pilot Study. Cureus. 2025 Nov 11;17(11):e96559. doi: 10.7759/cureus.96559. eCollection 2025 Nov.
PMID: 41393743DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 6 Months
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 17, 2024
First Posted
April 30, 2024
Study Start
April 30, 2024
Primary Completion
April 30, 2025
Study Completion
December 31, 2025
Last Updated
April 30, 2024
Record last verified: 2024-04