Idiopathic Generalized Epilepsy Syndromes

NCT06388174 | Recruiting

• 1 other identifier: S2022-0336
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The idiopathic generalized epilepsies (IGEs) have historically included the syndromes childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and epilepsy with generalized tonic-clonic seizures alone (GTCA). Recognition of the IGEs is important for clinical care, as it informs diagnosis, prevents unnecessary investigation, allows optimal selection of anti-seizure medications (ASMs), and provides prognostic guidance. According to the new ILAE definition in 2022, the study aims to describe the clinical features, electroencephalographic, imaging findings and long-term prognosis.

Conditions

Epilepsy; Epilepsy, Idiopathic Generalized

Outcome Measures

Primary Outcomes (2)

• The proportion of drug-resistent epilepsy

  We defined drug-resistant cases as those patients who have failed two or more trials of broad-spectrum ASMs or those otherwise indicated in IGE syndromes

  through study completion, an average of 1 year

• The proportion of seizure freedom

  We defined seizure freedom according to the International League Against Epilepsy (ILAE) definition

  through study completion, an average of 1 year

Secondary Outcomes (3)

• The proportion of psychiatric comorbidity

  through study completion, an average of 1 year

• The proportion of psychosocial outcome

  through study completion, an average of 1 year

• The proportion of seizure relapse after antiseizure medication withdrawn

  through study completion, an average of 1 year

Eligibility Criteria

• Age: 4 Years - 40 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patients are consecutively and prospectively recruited from epilepsy center and clinics

You may qualify if:

• Patients are consecutively and prospectively enrolled from epilepsy center, with newly diagnosed epilepsy or established epilepsy.
• Patients have a diagnosis of idiopathic generalized epilepsy (IGE), according to the 2022 diagnostic criteria.
• Comprehensive clinical information is collected, and 24 hour video-electroencephalography is performed.
• Sign the informed consent forms.

You may not qualify if:

• Other epilepsy syndromes are considered during follow-up, such as genetic generalized epilepsy.
• Lost to follow-up

Sponsors & Collaborators

• Shen Chun-Hong: lead

Study Sites (1)

2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

Hangzhou, Zhejiang, 310000, China

RECRUITING

MeSH Terms

Conditions

Epilepsy; Epilepsy, Idiopathic Generalized

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Chunhong Shen

  Second Affiliated Hospital, School of Medicine, Zhejiang University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Chunhong Shen

CONTACT

+86 0571 87783872; shen_neurology@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Senior Doctor

Study Record Dates

• First Submitted: April 16, 2024
• First Posted: April 29, 2024
• Study Start: January 1, 2023
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2033
• Last Updated: August 27, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)