Residual Neuromuscular Block in the Post-Anesthetic Unit and Postoperative Complications

NCT06386354 | Recruiting

• 1 other identifier: 2023-464-1
• Study Type: observational
• Target: 296
• Locations: 1 country
• Sites: 2

Brief Summary

The use of neuromuscular blockers (NMB) is essential to optimize surgical conditions, ensure patient immobility during the intervention and prevent complications derived from involuntary movements. Intraoperative monitoring of neuromuscular relaxation allows the depth of neuromuscular blockade to be accurately evaluated, guaranteeing ideal conditions for the surgical team. Residual neuromuscular blockade (RNMB) is the persistence of muscle paralysis after the administration of NMB during a surgical intervention. The appearance of RNMB poses substantial challenges in the postoperative period, as it has negative repercussions for the safety and well-being of the patient.

Conditions

Postoperative Neuromuscular Block; Postoperative Complications

Keywords

General Anesthesia; Neuromuscular block

Outcome Measures

Primary Outcomes (2)

• Residual Neuromuscular Block

  Train-Of-Four ratio at arrival to the Post-Anesthetic Care Unit

  5 minutes postoperatively

• Residual Neuromuscular Block

  Train-Of-Four ratio 3 minutes after the arrival to the Post-Anesthetic Care Unit

  8 minutes postoperatively

Secondary Outcomes (1)

• Postoperative complications

  30 days postoperatively

Study Arms (1)

Patients submitted to General Anesthesia with Neuromuscular Block

Patients submitted to General Anesthesia with Neuromuscular Block

Diagnostic Test: Train-of-four

Interventions

Train-of-four DIAGNOSTIC_TEST

Patients submitted to general anesthesia with neuromuscular block will be monitored at their arrival to the Post-Anesthesia Care Unit to assess the presence of residual neuromuscular block.

Patients submitted to General Anesthesia with Neuromuscular Block

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing surgical intervention under general anesthesia that requires the use of neuromuscular block during the study time.

You may qualify if:

• Patient undergoing surgical intervention under general anesthesia that requires the use of neuromuscular block during the study time and that required hospital admission.
• Informed consent signature.

You may not qualify if:

• Neuromuscular disease
• Not having received neuromuscular block during the intervention
• Admission to the outpatient surgery unit
• Admission to the postoperative intensive care unit
• Patients who signed informed consent, but postoperative data could not be collected upon arrival at the PACU.

Sponsors & Collaborators

• Dr. Negrin University Hospital: lead

Study Sites (2)

Hospital Universitario de Gran Canaria Doctor Negrín

Las Palmas de Gran Canaria, Las Palmas, 35010, Spain

RECRUITING

Ángel Becerra

Las Palmas de Gran Canaria, Las Palmas, 35019, Spain

RECRUITING

MeSH Terms

Conditions

Postoperative Complications

Interventions

Neuromuscular Monitoring

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Monitoring, Physiologic; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

Ángel Becerra Bolaños, PhD

CONTACT

+34928450370; angbecbol@gmail.com

Aurelio Rodríguez Pérez, PhD

CONTACT

+34928450370; arodperp@gobiernodecanarias.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: April 23, 2024
• First Posted: April 26, 2024
• Study Start: May 1, 2024
• Primary Completion: October 30, 2025
• Study Completion: October 30, 2025
• Last Updated: August 24, 2025

Record last verified: 2025-08

Locations

ES (2)