The Effect of Analgesia Methods Applied in Gynecological Cancer Surgeries on Postoperative Analgesia

NCT06382376 | Completed

• 1 other identifier: 2024-60
• Study Type: observational
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to compare the effectiveness of intrathecal morphine and four-quadrant transversus abdominis plane block applied for postoperative analgesia in gynecological cancer surgeries. The key question(s) it aims to answer are: \[Is intrathecal morphine more effective in postoperative analgesia?\] Patients who underwent gynecological cancer surgery were examined retrospectively. The investigators evaluated the effect of intrathecal morphine and four-quadrant transversus abdominis plane block applied for postoperative analgesia on pain scores and postoperative opioid use.

Conditions

Gynecological Cancer Surgery; Regional Anesthesia Morbidity

Keywords

gynecological cancer surgery; periferal block; neuraxial block

Outcome Measures

Primary Outcomes (1)

• postoperative numerical rating scale

  Our primary aim was to evaluate numerical rating scale at 24 hours postoperatively. numerical rating scale(NRS) was used to assess postoperative pain. NRS values were recorded For example, 0-10 where 0 is no pain and 10 is the worst pain imaginable.

  24 hours postoperatively

Secondary Outcomes (1)

• postoperative opioid use

  24 hours postoperatively

Study Arms (2)

Group 1: Intrathecal morphine administered group

Group 1: Intrathecal morphine administered group

Procedure: Intrathecal morphine administered group, Four quadrant transversus abdominis plane block applied group

Group 2: Four quadrant transversus abdominis plane block applied group

Group 2: Four quadrant transversus abdominis plane block applied group

Procedure: Intrathecal morphine administered group, Four quadrant transversus abdominis plane block applied group

Interventions

Intrathecal morphine administered group, Four quadrant transversus abdominis plane block applied group PROCEDURE

Intrathecal morphine administered group and Four quadrant transversus abdominis plane block applied group

Also known as: Group 1: Intrathecal morphine administered group, Group 2: Four quadrant transversus abdominis plane block applied group

Group 1: Intrathecal morphine administered group; Group 2: Four quadrant transversus abdominis plane block applied group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Between June 1, 2023 and December 1, 2023, 71 patients over the age of 18 who underwent surgery for ASA II and III gynecological cancer, to whom we applied intrathecal morphine or four-quadrant transversus abdominis plane block (TAPB) from peripheral nerve blocks for postoperative analgesia, were included in the study.

You may qualify if:

• years
• Patients who have undergone gynecological cancer surgery

You may not qualify if:

• \<18 years
• Those with missing data

Sponsors & Collaborators

• Bakirkoy Dr. Sadi Konuk Research and Training Hospital: lead

Study Sites (1)

Başakşehir Çam and Sakura City Hospital

Istanbul, Basaksehir, Turkey (Türkiye)

Location

Related Publications (4)

• Black KA, Nelson G, Goucher N, Foley J, Pin S, Chong M, Ghosh S, Bisch SP. Effect of transversus abdominis plane block on postoperative outcomes in gynecologic oncology patients managed on an Enhanced Recovery After Surgery pathway. Gynecol Oncol. 2023 Nov;178:1-7. doi: 10.1016/j.ygyno.2023.09.003. Epub 2023 Sep 18.

  PMID: 37729808 RESULT

• Niraj G, Kelkar A, Hart E, Kaushik V, Fleet D, Jameson J. Four quadrant transversus abdominis plane block and continuous transversus abdominis plane analgesia: a 3-year prospective audit in 124 patients. J Clin Anesth. 2015 Nov;27(7):579-84. doi: 10.1016/j.jclinane.2015.07.005. Epub 2015 Aug 28.

  PMID: 26319886 RESULT

• Pirie K, Traer E, Finniss D, Myles PS, Riedel B. Current approaches to acute postoperative pain management after major abdominal surgery: a narrative review and future directions. Br J Anaesth. 2022 Sep;129(3):378-393. doi: 10.1016/j.bja.2022.05.029. Epub 2022 Jul 6.

  PMID: 35803751 RESULT

• Meylan N, Elia N, Lysakowski C, Tramer MR. Benefit and risk of intrathecal morphine without local anaesthetic in patients undergoing major surgery: meta-analysis of randomized trials. Br J Anaesth. 2009 Feb;102(2):156-67. doi: 10.1093/bja/aen368.

  PMID: 19151046 RESULT

Study Officials

• Duygu Akyol

  Başakşehir Çam & Sakura City Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Month
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 20, 2024
• First Posted: April 24, 2024
• Study Start: June 1, 2023
• Primary Completion: December 1, 2023
• Study Completion: March 1, 2024
• Last Updated: April 26, 2024

Record last verified: 2024-04

Locations

TU (1)