Tracing Brain Tumors Through Deep Time

NCT06381531 | Recruiting DMC

• 1 other identifier: 4410
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

Brain tumors involve different age groups with a wide range of tumor types involving different anatomical compartments of the brain. The evolution of the brain in vertebrates, including the most recent homo species (including humans), has occurred through increasing structural complexity in more evolved species. In the retrospective study, we will investigate the location of the tumors and different structural aspects of skull anatomy in patients with brain tumors. The information will be compared with the anatomical evolution of the brain and skull in vertebrates to look for possible associations, which can provide insights into evolutionary biology.

Conditions

Brain Tumor; Oncology

Keywords

CNS tumor; Brain tumor; Evolution

Outcome Measures

Primary Outcomes (1)

• Age-based density maps of brain tumor location

  Tumor location for different age groups will be analyzed using proportions (percentage of tumor area in normal brain).

  36 months

Secondary Outcomes (1)

• Anthropometric analysis of skulls

  36 months

Interventions

Imaging with CT and MRI DIAGNOSTIC_TEST

Quantitative and anthropometric analysis of brain and skull strutcure of imaging (CT/ MRI) undertaken as part of diagnosis or treatment for patients with brain tumor

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with diagnosis of primary brain tumors will be screened for the study. Approximately 500-600 patients are treated annually with radiation in our center with available CT data for radiation planning, and another 100-200 patients having pre-operative or post-operative scans. For the above-mentioned time period, data is expected to be available from approximately 10,000 patients, which will be the upper limit of sample size for the current study.

You may qualify if:

• All patients diagnosed with primary brain tumors with available pre/ post-operative or pre-radiation brain images with computed tomography (CT) or magnetic resonance imaging (MRI)

You may not qualify if:

• CT/ MRI is not available before cranial radiotherapy
• Artifacts causing distortion of skull (bony) anatomy

Sponsors & Collaborators

• Tata Memorial Centre: lead
• Indian Statistical Institute, Kolkata: collaborator

Study Sites (1)

Tata Memorial Hospital

Mumbai, Maharashtra, 400012, India

RECRUITING

MeSH Terms

Conditions

Brain Neoplasms; Neoplasms; Central Nervous System Neoplasms

Interventions

Diagnostic Imaging; Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Nervous System Neoplasms; Neoplasms by Site; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis; Tomography

Study Officials

• ARCHYA DASGUPTA, MD

  Tata Memorial Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

ARCHYA DASGUPTA, MD

CONTACT

91-22-24177000; archya1010@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor, Radiation Oncology

Study Record Dates

• First Submitted: April 18, 2024
• First Posted: April 24, 2024
• Study Start: January 10, 2025
• Primary Completion (Estimated): June 10, 2027
• Study Completion (Estimated): June 10, 2027
• Last Updated: April 11, 2025

Record last verified: 2025-04

Locations

IN (1)