How Does Pianistic Musical Training Influence the Development of Alzheimer's Disease?

NCT06378372 | Not Yet Recruiting

• 1 other identifier: ETICA-ULE-064-2023
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn about and describe how pianistic training influences the development of Alzheimer's disease. The key question is: Can pianistic practice influence the development of Alzheimer's disease? Participants will receive piano lessons for 4 weeks (20 sessions) and we will evaluate the evolution of the different parameters described by the tests carried out.

Conditions

Dementia of Alzheimer Type; Dementia; Dementia, Vascular; Dementia, Mixed; Dementia Frontal; Dementia With Lewy Bodies; Cognitive Decline; Neurologic Disorder; Neurologic Dysfunction; Neurologic Deficits

Keywords

Alzheimer; Neuropsicology; Music; Piano; Rehabilitación; Music Theraphy

Outcome Measures

Primary Outcomes (8)

• State of global deterioration

  GDS 1 - 7

  Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention.

• Minimental Test

  0-24

  Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention.

• RDRS-2 Rapid Disability Assessment Scale

  18-72

  Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention.

• MONTREAL COGNITIVE ASSESSMENT (MOCA)

  0-30

  Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention.

• WAIS-IV

  0-160

  Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention.

• Behavioral disorders: BEHAVE-AD

  Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention.

• NPI - CUMMINGS

  0-120

  Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention.

• Evaluation of the caregiver's burden (Zarit test)

  0-88

  Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention.

Study Arms (1)

Grupo 0

EXPERIMENTAL

Group on which the pianistic intervention will be carried out

Behavioral: Music therapy based on piano learning

Interventions

Music therapy based on piano learning BEHAVIORAL

The intervention will consist of pianistic training. Patients will receive piano classes adapted to their competence designed to achieve motor, sensory and behavioral control.

Grupo 0

Eligibility Criteria

• Age: 50 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Patients in State of global deterioration Levels GDS 2 3 and 4.

You may not qualify if:

• Other patients in GDS groups (not 2, 3 and 4)
• The selected subject does not cooperate during intervention.

Sponsors & Collaborators

• David Franco Castellanos: lead
• Jesús Ángel Seco Calvo: collaborator
• Javier Tejada Garcia: collaborator

Study Sites (1)

Universidad de León

León, Castille and León, 24004, Spain

Location

Related Publications (15)

• Alzheimer´s Association. (2020). 2020 Alzheimer´s Disease Facts and Figures. Alzheimer´s & Dementia: The Journal of the Alzheimer Association, 16(3), 391-460. Doi: 10.1002/alz.12068

  BACKGROUND

• Baird A, Samson S. Memory for music in Alzheimer's disease: unforgettable? Neuropsychol Rev. 2009 Mar;19(1):85-101. doi: 10.1007/s11065-009-9085-2. Epub 2009 Feb 13.

  PMID: 19214750 BACKGROUND

• Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994 Dec;44(12):2308-14. doi: 10.1212/wnl.44.12.2308.

  PMID: 7991117 BACKGROUND

• Hanna-Pladdy B, MacKay A. The relation between instrumental musical activity and cognitive aging. Neuropsychology. 2011 May;25(3):378-86. doi: 10.1037/a0021895.

  PMID: 21463047 BACKGROUND

• López O, Tratamiento farmacológico de la enfermedad de Alzheimer y otras demencias. (2015) Recuperado de: http://www.scielo.edu.uy/scielo.php?pid=S1688-423X2015000200003&script=sci_arttext&tlng=pt

  BACKGROUND

• Maurer K, Maurer U. Alzheimer. La vida de un médico, la historia de una enfermedad. Madrid: Díaz de Santos; 2006.

  BACKGROUND

• MSCBS. Ministerio de Sanidad, Consumo y Bienestar Social (2019) Plan integral de Alzheimer y otras Demencias (2019-2023) Recuperado de: https://mscbs.gob.es/profesionales/saludPublica/docs/Plan_Integral_Alzheimer_Octubre_2019.pdf

  BACKGROUND

• NINDS. National Institute of Neurological Disorders and Stroke. (2019). Recuperado de: https://www.ninds.nih.gov/Disorders/All-Disorders/Alzheimers-Disease Information-Page

  BACKGROUND

• Paxinos, G. y Mai, J. (2004). The human nervous system. Academic Press, Inc.

  BACKGROUND

• Peretz I, Zatorre RJ. Brain organization for music processing. Annu Rev Psychol. 2005;56:89-114. doi: 10.1146/annurev.psych.56.091103.070225.

  PMID: 15709930 BACKGROUND

• Sclan S, Saillon A, Franssen E, et al. The behavior pathology in Alzheimer's disease ratings scale (BEHAVE-AD): reability and analisys of symptom category scores. Int J Geriatr Psychiatry, 1996; 11: 819-830.

  BACKGROUND

• Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM. Alzheimer's disease. Lancet. 2016 Jul 30;388(10043):505-17. doi: 10.1016/S0140-6736(15)01124-1. Epub 2016 Feb 24.

  PMID: 26921134 BACKGROUND

• Sultzer DL, Levin HS, Mahler ME, High WM, Cummings JL. Assessment of cognitive, psychiatric, and behavioral disturbances in patients with dementia: the Neurobehavioral Rating Scale. J Am Geriatr Soc. 1992 Jun;40(6):549-55. doi: 10.1111/j.1532-5415.1992.tb02101.x.

  PMID: 1587970 BACKGROUND

• Tariot PN, Mack JL, Patterson MB, Edland SD, Weiner MF, Fillenbaum G, Blazina L, Teri L, Rubin E, Mortimer JA, et al. The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease. Am J Psychiatry. 1995 Sep;152(9):1349-57. doi: 10.1176/ajp.152.9.1349.

  PMID: 7653692 BACKGROUND

• Valenzuela MJ, Sachdev P. Brain reserve and dementia: a systematic review. Psychol Med. 2006 Apr;36(4):441-54. doi: 10.1017/S0033291705006264. Epub 2005 Oct 6.

  PMID: 16207391 BACKGROUND

MeSH Terms

Conditions

Dementia; Dementia, Vascular; Mixed Dementias; Lewy Body Disease; Cognitive Dysfunction; Nervous System Diseases; Neurologic Manifestations

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Cerebrovascular Disorders; Intracranial Arteriosclerosis; Intracranial Arterial Diseases; Leukoencephalopathies; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Cognition Disorders; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• David Franco-Castellanos, Sr

  Universidad de León

  PRINCIPAL INVESTIGATOR

Central Study Contacts

David Franco-Castellanos, Sr

CONTACT

0034676099644; dfrac@unileon.es

Jesus Angel Seco-Calvo, Sr

CONTACT

987293127; jesus.seco@unileon.es

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant professor

Model Details: An intervention based on teaching the piano in an individualized way

Study Record Dates

• First Submitted: April 18, 2024
• First Posted: April 22, 2024
• Study Start: June 1, 2024
• Primary Completion: August 1, 2024
• Study Completion: June 1, 2025
• Last Updated: April 22, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)