Boosting The Intervention Effect of Negative Memory Through tACS Stimulation

NCT06375395 | Unknown DMC

• 1 other identifier: Memory Updating Tasks
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The objectives of this study include: 1) investigating the impact of negative memory substitution on an individual's other intellectual memories (i.e., neutral memories) and the underlying neurocognitive mechanisms; 2) investigating the memory enhancement effect resulting from retrieval practice associated with memory substitution intervention along with an examination of the neurocognitive mechanisms responsible for this enhancement.

Conditions

Seizures

Keywords

seizure; transcranial alternating current stimulation; neuromodulation; negative memory; neural mechanisms; retrieval practice; working memory

Outcome Measures

Primary Outcomes (1)

• Negative memory retention

  The intervention could disrupt retention of associative negative memory and degree of detail of the negative memories in last A-C paired associate memory test.

  Day 5

Secondary Outcomes (3)

• The negative emotional intensity of negative memory

  Day 5

• The retention of associated neutral memories as assesses by the proportions of responses of correctly choosing picture category of B picture (A-Bneu) in last A-B paired associate memory test

  Day 5

• The negative emotional intensity of neutral memory

  Day 5

Study Arms (2)

Active tACS

EXPERIMENTAL

Those who participate in the treatment group will receive tACS, which lasts for 40 minutes per day on 3 consecutive days.

Device: Active tACS Device

Sham tACS

PLACEBO COMPARATOR

Those who participate in the control group will receive sham tACS, which lasts for 40 minutes per day on 3 consecutive days.

Device: Sham tACS Device

Interventions

Active tACS Device DEVICE

Transcranial Alternating Current Stimulation

Active tACS

Sham tACS Device DEVICE

Placebo Device that simulates active tACS treatment

Sham tACS

Eligibility Criteria

• Age: 14 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• years old, male or female, Han Chinese;
• Drug-resistant epilepsy;
• Required surgical implantation of SEEG electrodes.

You may not qualify if:

• Progressive encephalopathy or progressive structural damage in the central nervous system;
• Significant heart, liver, renal insufficiency, and other medical diseases;
• Severe side effects from taking antiepileptic drugs at the time of enrollment and not inappropriate for SEEG;
• Significant intellectual disability;
• A history of alcohol and drug abuse;
• Any contraindication to MRI.

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead
• Beijing Normal University: collaborator

MeSH Terms

Conditions

Seizures

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Guoguang Zhao

  Xuanwu Hospital, Beijing

  STUDY DIRECTOR

Central Study Contacts

Hongxing Wang, MD & PhD

CONTACT

01083198513; hxwang8888@126.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 1, 2024
• First Posted: April 19, 2024
• Study Start: August 15, 2024
• Primary Completion: December 15, 2024
• Study Completion: December 31, 2024
• Last Updated: August 7, 2024

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share