Effect of Stellate Ganglion Block on Postoperative Nausea and Vomiting

NCT06371131 | Unknown

• 1 other identifier: PONV of Thyroid Surgery
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative nausea and vomiting is one of the most common postoperative complications second only to postoperative pain. Studies have reported that without any antiemetic prevention treatment, the overall incidence of PONV in surgical operations is up to 20-30%, and the incidence of PONV in high-risk patients such as thyroid surgery is even up to 70-80%. PONV not only increased discomfort and prolonged hospital stay; Severe cases can lead to wound dehysis, acid-base imbalance, water and electrolyte metabolism disorders, seriously affect the prognosis of patients. Although various prevention and treatment measures have been adopted in clinical practice, it still cannot be completely eliminated. Therefore, postoperative nausea and vomiting of thyroid is still a concern in clinical anesthesia work, so it is urgent to explore more simple and effective measures to prevent thyroid PONV. SGB is the injection of local anesthetics into loose connective tissue containing stellate ganglion. It has a clear effect on postoperative analgesia of thyroid surgery, and can play a certain role in preventing thyroid PONV by reducing the application of perioperative opioids. Few studies have reported that the incidence of PONV can be significantly reduced after the application of SGB in patients with thyroid surgery, which provides a certain basis for the prevention of thyroid PONV. Therefore, this study aims to explore the effect of right stellate ganglion block on preventing postoperative nausea and vomiting of thyroid, and to explore the possible mechanism of action.

Conditions

Stellate Ganglion Block; Thyroid Surgery; Postoperative Nausea and Vomiting

Outcome Measures

Primary Outcomes (1)

• Incidence of Postoperative nausea and vomiting

  Postoperative nausea and vomiting is evaluated by follow-up

  From end of surgery to 24 hours after surgery

Secondary Outcomes (8)

• Incidence of Postoperative nausea and vomiting during preemptive analgesia

  From 0-10 min after preemptive analgesia

• Intensity of nausea and vomiting during preemptive analgesia

  From 0-10 min after preemptive analgesia

• Intensity of nausea and vomiting during hospitalization

  From end of surgery to 24 hours after surgery

• Hemodynamic parameters after preemptive analgesia

  From 0-10 min after preemptive analgesia

• Postoperative pain intensity

  From end of surgery to 24 hours after surgery

Study Arms (2)

Right stellate ganglion block

EXPERIMENTAL

Right -stellate ganglion block was given 30minutes before anesthesia induction.

Procedure: Right -stellate ganglion block

Blank control group

NO INTERVENTION

No treatment was given 30 minutes before anesthesia induction

Interventions

Right -stellate ganglion block PROCEDURE

The experimental group was given right stellate ganglion block 30 minutes before anesthesia induction

Right stellate ganglion block

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Receiving thyroid surgery under general anesthesia
• Age ≥18 years and ≤ 70 years
• American Society of Anesthesiologists(ASA) physical status classification I-III.
• Voluntary participation and ability to understand and sign the informed consent form.

You may not qualify if:

• Patients with obesity(BMI\>30 kg/m2)
• contraindicated to stellate ganglion block

Sponsors & Collaborators

• The Second Affiliated Hospital of Chongqing Medical University: lead

Study Sites (1)

The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400000, China

RECRUITING

MeSH Terms

Conditions

Postoperative Nausea and Vomiting

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Signs and Symptoms; Vomiting

Study Officials

• ling Dan, BD

  The Second Affiliated Hospital of Chongqing Medical University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

ling Dan, BD

CONTACT

13983072922; 302069@hospital.cqmu.edu.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Experimental group: right stellate ganglion block 30 minutes before anesthesia induction.Control group: No treatment was given 30minutes before anesthesia induction.Data was recorded at the corresponding time points.

Study Record Dates

• First Submitted: April 14, 2024
• First Posted: April 17, 2024
• Study Start: April 17, 2023
• Primary Completion: May 30, 2024
• Study Completion: August 30, 2024
• Last Updated: April 26, 2024

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will share

Locations

CN (1)