Effect of Right-stellate Ganglion Block in Preventing Postoperative Nausea and Vomiting in Gynecological Laparoscopic Patients

NCT06426186 | Completed

• 1 other identifier: PONV-Gynecological surgery
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative nausea and vomiting is one of the common postoperative complications. Studies have reported that without any antiemetic prevention treatment, the overall incidence of PONV in surgical operations is up to 20-30%, and the incidence of PONV in high-risk operations such as gynecological laparoscopy is higher. Postoperative nausea and vomiting can lead to perioperative complications and seriously affect the prognosis of patients. Although various preventive and therapeutic measures have been adopted in clinic, the incidence of perioperative nausea and vomiting is still high. Therefore, it is of great clinical significance to explore more effective and feasible methods to prevent the occurrence of PONV. Stellate ganglion block has been proved to be widely used in clinic and can play a positive role in multiple organs and systems of the whole body. In clinical work, stellate ganglion block is more widely used in the treatment of various pain, autonomic nerve disorders and other diseases. However, there are few clinical studies on whether stellate ganglion block can be used as an effective and feasible means to prevent postoperative nausea and vomiting and the related mechanisms to prevent the possible occurrence of nausea and vomiting. Therefore, this project aims to explore the preventive effect of stellate ganglion block on postoperative nausea and vomiting in gynecological laparoscopic surgery patients, and to explore its possible mechanism.

Conditions

Postoperative Nausea and Vomiting

Outcome Measures

Primary Outcomes (1)

• The incidence of postoperative nausea and vomiting

  Postoperative nausea and vomiting is evaluated by follow-up

  From end of surgery to 24 hours after surgery

Secondary Outcomes (8)

• Incidence of nausea and vomiting during preemptive analgesia

  From 0-10 minutes after preemptive analgesia

• Intensity of nausea and vomiting during preemptive analgesia

  From 0-10 minutes after preemptive analgesia

• Intensity of nausea and vomiting during hospitalization

  From end of surgery to 24 hours after surgery

• Hemodynamic parameters

  When patients enter the operation room (T0),Immediately before intubation（T1，about 30minutes after SGB）,Immediately after intubation（T2，about 35minutes after SGB）， trendelenburg position after completion (T3)，At the end of the operation（T4）

• Postoperative pain intensity

  From end of surgery to 24 hours after surgery

Study Arms (2)

Right-stellate ganglion block

EXPERIMENTAL

Right-stellate ganglion block was given 30 minutes before anesthesia induction

Procedure: Right-stellate ganglion block

Blank control group

NO INTERVENTION

No treatment was given 30 minutes before anesthesia induction

Interventions

Right-stellate ganglion block PROCEDURE

The experimental group was given right stellate ganglion block 30 minutes before anesthesia

Right-stellate ganglion block

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥18 years and ≤ 70 years
• American Society of Anesthesiologists(ASA) physical status classification I-Ill.
• Voluntary participation and ability to understand and sign the informed consent form
• Patients undergoing gynecological laparoscopic surgery elective general anesthesia

You may not qualify if:

• Patients with obesity(BMI\>30kg/m2)
• Contraindicated to stellate ganglion block

Sponsors & Collaborators

• The Second Affiliated Hospital of Chongqing Medical University: lead

Study Sites (1)

The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400000, China

Location

Related Publications (1)

• Liu Y, Piao G, Chen J, Duan G, Dan L, Chen G, Zhang Y. Effect of Right Stellate Ganglion Block on Preventing Postoperative Nausea and Vomiting in Gynecological Laparoscopic Patients: A Randomized Controlled Trial. Adv Ther. 2025 Mar;42(3):1537-1549. doi: 10.1007/s12325-025-03109-7. Epub 2025 Feb 10.

  PMID: 39928244 DERIVED

MeSH Terms

Conditions

Postoperative Nausea and Vomiting

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Signs and Symptoms; Vomiting

Study Officials

• ling Dan, BD

  The Second Affilated Hospital of Chongqing Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 14, 2024
• First Posted: May 23, 2024
• Study Start: June 9, 2023
• Primary Completion: June 27, 2024
• Study Completion: June 27, 2024
• Last Updated: July 29, 2024

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will share

Locations

CN (1)