Treatment Optimization and Nephrolithiasis Recurrence Prevention With Interdisciplinary Care

NCT06367894 | Recruiting

• 1 other identifier: STONECARE
• Study Type: observational
• Target: 164
• Locations: 1 country
• Sites: 1

Brief Summary

Nearly 10% of the Belgian population suffer from kidney stone disease. Recent reviews reported that kidney stones represent an underestimated risk factor for further kidney function deterioration. Preventive measures are recommended in lithiases patients to prevent the formation of new stones. The individual effects of different medicated prosthetic interventions have been documented in clinical trials. However, there is little data on the effectiveness of combining these different preventive measures in routine clinical practice (real-world context). Patients with kidney stone disease require a complete metabolic assessment. The three main factors contributing to the stone's formation are the patient's metabolism, diet and lifestyle. Metabolic work-up is recommended by the American Urology Association to identify and correct the factors responsible for urinary stone formation such as hypercalciuria, hyperoxaluria, hyperuricuria, hypocitraturia or abnormalities of urinary pH. The metabolic work-up includes at minimum the 24h urine test, a blood test and spot urine test. Dietary habits and lifestyle are assessed by means of a questionnaire. The CHU Brugmann Hospital has a specialized multidisciplinary clinic for renal lithiases and mineral metabolism. Preventive personalized and interdisciplinary care in CHU Brugmann consists of a full metabolic work-up allowing the identification of lithogenic risk factors by nephrologists, dietary assessment by specialized dieticians and specific treatment protocol associated with regular follow-up. The aim of this study is to evaluate, in the context of a retrospective single-center cohort study, the effect of preventive personalized and interdisciplinary care on the evolution of all urinary lithogenic risk factors and the recurrence of kidney stones (rate of renal colics, emergency room admissions, and urological interventions).

Conditions

Kidney Stone

Outcome Measures

Primary Outcomes (7)

• Number of acute renal colics

  Number of acute renal colics

  From first patient consultation till 31/10/2023

• Number of emergency admissions

  Number of emergency admissions

  From first patient consultation till 31/10/2023

• Number of surgeries

  Number of surgeries

  From first patient consultation till 31/10/2023

• Number of hospitalizations

  Number of hospitalizations

  From first patient consultation till 31/10/2023

• Identified genetics abnormalities

  List of identified genetics abnormalities

  From first patient consultation till 31/10/2023

• Wisconsin questionnaire

  Changes in the quality of life in the patients (evolution of the scoring of the Wisconsin questionnaire)

  From first patient consultation till 31/10/2023

• Kidney function outcome

  Kidney function outcome

  Status at 31/10/2023

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients of the CHU Brugmann Hospital who fulfill the criteria of active or past history of kidney stone, from 01/01/2018 till 31/10/2023

You may qualify if:

• All patients of the CHU Brugmann Hospital who fulfill the criteria of active or past history of kidney stone, from 01/01/2018 till 31/10/2023
• Minimum follow-up time of 2 months with biochemical and clinical results available

You may not qualify if:

• \- None

Sponsors & Collaborators

• Agnieszka Pozdzik: lead

Study Sites (1)

CHU Brugmann

Brussels, 1020, Belgium

RECRUITING

MeSH Terms

Conditions

Kidney Calculi

Condition Hierarchy (Ancestors)

Nephrolithiasis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Urinary Calculi; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Sirika Chhem

CONTACT

024772641; Sirika.Chhem@ulb.be

Agnieszka POZDZIK

CONTACT

024752639; Agnieszka.POZDZIK@chu-brugmann.be

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Head of nephrology clinic

Study Record Dates

• First Submitted: April 11, 2024
• First Posted: April 16, 2024
• Study Start: December 12, 2023
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: April 16, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)