Metabolic Risk Factors and Stones Composition in Adult Kidney Stone Formers

NCT04243772 | Completed

• 1 other identifier: Metastone study
• Study Type: observational
• Target: 350
• Locations: 1 country
• Sites: 1

Brief Summary

Within the CHU Brugmann hospital, a multidisciplinary Renal Lithiasis and Mineral Metabolism clinic has been inaugurated in 2017. During the first months of 2018, the activities of the clinic have been focalized on the pre-analytical and analytical aspects of metabolic work-up. 15 patients are followed on average per week. The clinic is recognized as one of the 24 core centers of the European Nephrolithiasis Network and it is the only clinic included in this network in Belgium. The actual practice of the clinic has been published in a survey regarding current practice patterns of stone centers across Europe. Following this publication, the members of the board of the European Nephrolithiasis Network have put as common effort to standardize the care of kidney stone formers and obtained endorsement to perform a second survey in each core center. The aim of this initiative is to share information from real patients in aggregate form. Each core center practice will be evaluated by the second survey by an analysis of the robustness of clinical, biological, urological and radiological data. The main aim of this project consists in the constitution of a clinical, biological, urological and radiological database of followed patients. This database could be shared in aggregate form by using a specialized coding system for the patients. The database will enable the investigators to:

• describe the epidemiological and clinico-biological characteristics of the CHU Brugmann patient population
• gather information about the kidney function outcome
• analyze and classify identified prolithogenics factors
• characterize related metabolic disorders (diabetes mellitus, metabolic syndrome, arterial hypertension, chronic kidney diseases, osteoporosis...)
• identify the patients that could participate in the international trials on kidney stone disease
• identify the patients that will need a specialized genetic testing.
• evaluate the impact of the clinic activity and metabolic work-up on the rate of recurrence of kidney stones in the patient population. The obtained data will be compared with the global data from the European Nephrolithiasis Network.

Conditions

Kidney Stone

Outcome Measures

Primary Outcomes (3)

• Urinary tract stone composition

  Urinary tract stone composition

  3 years

• Metabolic screen results

  Metabolic screen (fasting blood) results

  3 years

• 24 hour urine screen results

  24 hour urine screen (first basal urine) results

  3 years

Study Arms (1)

Lithiasic patients

Lithiasic patients of the CHU Brugmann Hospital

Other: Data extraction

Interventions

Data extraction OTHER

Data extraction from medical files

Lithiasic patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients of the CHU Brugmann Hospital with active or past history of kidney stone (newly diagnosed or with relapse). Medical file data collection starts from 01 January 2018.

You may qualify if:

• Active or past history of kidney stone (newly diagnosed or with relapse)
• Age and sex matched controls from the hospital

You may not qualify if:

• \- None

Sponsors & Collaborators

• Agnieszka Pozdzik: lead

Study Sites (1)

CHU Brugmann

Brussels, 1020, Belgium

Location

MeSH Terms

Conditions

Kidney Calculi

Condition Hierarchy (Ancestors)

Nephrolithiasis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Urinary Calculi; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Mohamed El Mallouli

  CHU Brugmann

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Head of nephrology clinic

Study Record Dates

• First Submitted: January 24, 2020
• First Posted: January 28, 2020
• Study Start: November 12, 2019
• Primary Completion: December 12, 2023
• Study Completion: December 12, 2023
• Last Updated: April 12, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)