Resistance Exercise Training in the Older Population With Obesity

NCT06367296 | Recruiting DMC

• 1 other identifier: RETOPO2024
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 2

Brief Summary

Background: Aging leads to an alteration in the immune response, characterized by a chronic inflammatory state, and a progressive decrease in muscle quantity and quality, a situation that increases in women and in the presence of obesity. With respect to muscle quality, intramuscular infiltration of adipose tissue has been considered a relevant parameter, involved in the relationship between aging-obesity-inflammation. As a therapeutic strategy, physical training with resistance exercises (or also known as strength training) has been shown to be effective in increasing skeletal muscle mass in this age group. However, its role on muscle quality in normal-weight versus obese older women has not been fully addressed. Hypothesis: A 12-week resistance exercise training program is effective in improving muscle quality, immune response and physical performance in normal weight and obese older women. In addition to the above, the investigators hypothesize that women with obesity will present greater baseline alterations, so the percentage of change will be higher compared to older women with normal weight after the training program. Goals: The primary aim of this study is to evaluate the effects of a 12-week resistance exercise training on muscle quality (infiltration of intramuscular adipose tissue), immune response and physical performance in older women between 60 and 79 years of age with obesity compared to older women with normal weight of the same age range. Methodology: The present clinical trial will consider 2 groups of older women between 60 and 79 years old: normal weight (BMI=18.5 to 24.9 kg/m 2 and % fat \<25.9) and obese (BMI =30 to 39.9 Kg/m 2 and fat % \>32). Participants will perform 12 weeks of training with resistance exercises 3 times a week. Before and after training, intramuscular infiltration of adipose tissue (echogenicity) will be measured by ultrasound, followed by aspects of muscle architecture (muscle thickness, penile angle and fascicle length) and functional parameters of muscle quality (maximum strength determined by 1 repetition maximum-1RM, maximum voluntary isometric strength of knee extensors through a lower limb force and power transducer). Finally, fasting blood samples will be obtained (immune response) and physical performance, body composition, physical activity level, and quality of life will be evaluated.

Conditions

Aging; Obesity

Keywords

Strength training; Malnutrition due to excess; Biochemical markers; Clinical anatomy

Outcome Measures

Primary Outcomes (1)

• Change in intermuscular adipose tissue (measured via ultrasonography) after prolonged resistance-type exercise training

  Intramuscular adipose tissue infiltration evaluated by echointensity (Pixel Intensity 0 to 255) in the rectus femoris and vastus intermedius muscles of both lower limbs

  Before, and after 12 weeks of training

Secondary Outcomes (14)

• Change in muscle thickness (measured via ultrasonography) after prolonged resistance-type exercise training

  Before, and after 12 weeks of training

• Change in pennation angle (measured via ultrasonography) after prolonged resistance-type exercise training

  Before, and after 12 weeks of training

• Change in fascicle length (measured via ultrasonography) after prolonged resistance-type exercise training

  Before, and after 12 weeks of training

• Change in physical performance (measured via Short physical performance battery (SPPB)) after prolonged resistance-type exercise training

  Before, and after 12 weeks of training

• Change in arms and legs strength (measured via 1-Repetition Maximum (1RM) testing) after prolonged resistance-type exercise training

  Before, and after 12 weeks of training

Study Arms (2)

Normal Weight

EXPERIMENTAL

All volunteers Normal Weight: BMI=18.5 kg/m2 to 24.9 kg/m2 and % fat \<25.9%, n=16

Other: Prolonged resistance exercise training

Obese

EXPERIMENTAL

All volunteers Obesity: BMI= 30.0 kg/m2 to 39.9 kg/m2 m2 and % fat \> 32%, n=16.

Other: Prolonged resistance exercise training

Interventions

Prolonged resistance exercise training OTHER

Training with resistance exercises for upper and lower limbs will be carried out 3 times a week (Monday, Wednesday and Friday) for 12 weeks for all participants. The training will follow the guidelines of the American College of Sports Medicine ("American College of Sports Medicine Position Stand. Progression Models in Resistance Training for Healthy Adults," 2009) and will consist of a 5-minute cardiovascular warm-up on a cycle ergometer, followed by weight training. Resistance training will be carried out with exercise machines: 5 sets of leg press, leg extension and leg flexion for lower limbs and 3 sets of chest press and triceps extension for upper limbs. Subsequently, the participants will perform global flexibility exercises for 5 minutes to return to calm.

Normal Weight; Obese

Eligibility Criteria

• Age: 60 Years - 79 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Older women between 60 and 79 years old who live in the community, that is, they do not live in nursing homes or similar.
• Older people with normal weight (BMI=18.5 to 24.9 kg/m2 and % fat \<25.9) and those with obesity (BMI= 30 to 39.9 Kg/m2 and % fat \> 32).
• Cognitive ability to follow verbal orders.

You may not qualify if:

• Neuromuscular or mobility disorders that do not allow resistance training to be carried out safely (debilitating arthritis, spasticity/rigidity, neurological disorders and paralysis).
• Use of nutritional supplementation that can regulate skeletal muscle (leucine, glutamine, casein, whey-protein, fatty acids and creatine).
• Untreated and/or uncontrolled chronic diseases.
• Have carried out a training program with resistance exercises in the last 6 months.

Sponsors & Collaborators

• Universidad de La Frontera: lead

Study Sites (2)

Universidad de La Frontera

Temuco, IX Región de La Araucanía, 4780000, Chile

NOT YET RECRUITING

Gabriel Marzuca

Temuco, Región de la Araucanía, 4780000, Chile

RECRUITING

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• GABRIEL MARZUCA, Msc, PhD

  Universidad de La Frontera. Temuco, Chile

  STUDY DIRECTOR

Central Study Contacts

Nicolás Vidal-Seguel, MSc

CONTACT

998595445; nicolasenrique.vidal@ufrontera.cl

GABRIEL MARZUCA, MSc, PhD

CONTACT

996343630; gabriel.marzuca@ufrontera.cl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 2, 2024
• First Posted: April 16, 2024
• Study Start: July 1, 2024
• Primary Completion: January 28, 2025
• Study Completion: June 1, 2025
• Last Updated: January 27, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

CL (2)