Transcriptomic Analysis of Incisional Hernia Based on High-throughput Sequencing Technology

NCT06366581 | Completed

• 1 other identifier: HD20240307
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

This study included patients who underwent surgical treatment for incisional hernia and non-hernia conditions. Surgical specimens were collected for transcriptome sequencing to obtain the gene expression list. Then genes analyzed by Gene Ontology, protein interactions, and signaling pathway enrichment using the expression matrix.

Conditions

Incisional Hernia; Extracellular Matrix Alteration

Outcome Measures

Primary Outcomes (1)

• the gene expression list

  the gene expression list

  2023.3-2023.9

Study Arms (2)

IH group

Patients who underwent incisional hernia repair were defined as the experimental group (labelled as the IH group)

Diagnostic Test: Transcriptomic analysis

NC group

patients who underwent laparoscopic cholecystectomy were defined as the control group (labelled as the NC group)

Diagnostic Test: Transcriptomic analysis

Interventions

Transcriptomic analysis DIAGNOSTIC_TEST

high-throughput sequencing technology

IH group; NC group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who underwent incisional hernia repair were defined as the experimental group (labelled as the IH group), and patients who underwent laparoscopic cholecystectomy were defined as the control group (labelled as the NC group).

You may qualify if:

• to 75 years 2.diagnosed with incisional hernia 3.normal tumour markers 4.elective surgery patients.

You may not qualify if:

• patients with vital organ failure (heart liver, lung, kidney and others)
• malignant tumors not been completely relieved by active treatment,
• patients who have psychiatric diseases or comprehension disorders.
• patients with metabolic disease involving connective tissue collagen.

Sponsors & Collaborators

• Fudan University: lead

Study Sites (1)

Hua Dong Hospital Affiliated to Fu Dan University

Shanghai, China

Location

MeSH Terms

Conditions

Incisional Hernia

Condition Hierarchy (Ancestors)

Hernia; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Postoperative Complications; Pathologic Processes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: March 7, 2024
• First Posted: April 16, 2024
• Study Start: March 1, 2023
• Primary Completion: September 1, 2023
• Study Completion: March 1, 2024
• Last Updated: April 16, 2024

Record last verified: 2024-03

Locations

CN (1)