Transcriptomic Study of IBD-associated Colorectal Cancer

NCT05060770 | Completed

• 1 other identifier: 2021PI125
• Study Type: observational
• Target: 26
• Locations: 0 countries
• Sites: N/A

Brief Summary

Chronic inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC) in historical cohorts. The pathways of oncogenesis of these CRCs, which are very different clinically from de novo CRCs, are currently unknown. The aim of our work is to identify specific molecular signatures of CRC occurring in the setting of IBD.

Conditions

Colorectal Cancer, Genetics of

Keywords

inflammatory bowel disease

Outcome Measures

Primary Outcomes (1)

• IBD associated CRC oncogenesis

  Percentage of gene expression variation in CRC tumor tissue samples in the following groups patients with CRC and IBD

  1 year

Interventions

transcriptomic analysis GENETIC

transcriptomic analysis on preserved tumor tissue

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

\>/= 18 years old patient operated on at the Nancy university hospital for IBD associated CRC

You may qualify if:

• Person 18 years of age or older
• Person with colorectal cancer in the context of IBD
• Person who has received complete information on the organization of the research and who has signed an informed consent
• Person affiliated to a social security plan or beneficiary of such a plan.

You may not qualify if:

• Person referred to in articles L. 1121-5, L. 1121-7 and L1121-8 of the public health code:
• Pregnant woman, parturient or nursing mother
• Minor (not emancipated)
• Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
• Person of legal age who is unable to express his or her consent
• Person deprived of liberty by a judicial or administrative decision, persons subject to psychiatric care under articles L. 3212-1 and L. 3213-1.

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

MeSH Terms

Conditions

Colorectal Neoplasms; Inflammatory Bowel Diseases

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Gastroenteritis

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor (MD, PhD Student), Principal investigator

Study Record Dates

• First Submitted: September 19, 2021
• First Posted: September 29, 2021
• Study Start: January 1, 2010
• Primary Completion: January 1, 2021
• Study Completion: January 1, 2021
• Last Updated: October 7, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share