Muscle Oxygenation and Spasticity in Hemiparetic Stroke Patients

NCT06362954 | Completed

• 1 other identifier: GaziU-FTR-SS-01
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Conditions such as hemiparesis, sensory and motor impairment, perceptual impairment, cognitive impairment, aphasia, and dysphagia may be observed after stroke. Motor impairment after stroke may occur due to damage to any part of the brain related to motor control. There is much clinical evidence that damage to different parts of the sensorimotor cortex in humans affects other aspects of motor function. Loss of strength, spasticity, limb apraxia, loss of voluntary movements, Babinski sign, and motor neglect are typical motor deficits following a cortical lesion (upper motor neuron lesion). Post-stroke spasticity can be seen in 19% to 92% of stroke survivors. Post-stroke hemiparesis is a significant cause of morbidity and disability, along with abnormal muscle tone. It has also been recognized that post-stroke hemiparesis may occur without spasticity. Spasticity influences muscle hemodynamic and oxidative metabolism, but its impact on the balance between oxygen delivery and utilization is not well understood. This study study aims to investigate the effect of spasticity severity on peripheral muscle oxygenation in patients with hemiparetic stroke.

Conditions

Stroke; Hemiparesis;Poststroke/CVA; Spasticity as Sequela of Stroke

Keywords

stroke; paresis; spasticity; near-infrared spectroscopy; lower extremity

Outcome Measures

Primary Outcomes (2)

• Gastrocnemius Muscle Oxygenation

  Gastrocnemius muscle oxygenation will be evaluated with Near-Infrared Spectroscopy at rest, during and after the 6-Minute Walk Test (6MWT) and the Stair Climbing Test (SCT).

  Day 1

• Spasticity

  Plantar flexor muscle spasticity on the affected side will be evaluated with Modified Ashworth Scale

  Day 1

Secondary Outcomes (5)

• Motor Function

  Day 1

• Disability Level

  Day 1

• 6-Minute Walk Test

  Day 1

• Stair Climbing Test

  Day 1

• Adipose tissue thickness

  Day 1

Study Arms (3)

High-Level Spasticity Group

Hemiparetic stroke patients with spasticity levels greater than or equal 2 on the Modified Ashworth Scale.

Low-Level Spasticity Group

Hemiparetic stroke patients with spasticity levels less than 2 on the Modified Ashworth Scale.

Control Group

Healthy individuals were included in the control group.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Twenty patients with chronic hemiparetic stroke and 10 healthy controls was conducted at Gazi University, Faculty of Health Sciences, Outpatient Clinics.

Sponsors & Collaborators

• Ankara Medipol University: lead
• Gazi University: collaborator

Study Sites (1)

Gazi University, Faculty of Health, Department of Physiotherapy and Rehabilitation

Ankara, Turkey (Türkiye)

Location

Related Publications (1)

• Suicmez S, Yazici G, Altiparmak T, Cagatay C, Batur-Caglayan HZ, Nazliel B. The effect of spasticity severity on peripheral muscle oxygenation in hemiparetic stroke patients: a cross-sectional study. Top Stroke Rehabil. 2025 Jul 28:1-11. doi: 10.1080/10749357.2025.2538520. Online ahead of print.

  PMID: 40717605 DERIVED

MeSH Terms

Conditions

Stroke; Paresis; Muscle Spasticity

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Muscular Diseases; Musculoskeletal Diseases; Muscle Hypertonia; Neuromuscular Manifestations

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: April 9, 2024
• First Posted: April 12, 2024
• Study Start: April 15, 2024
• Primary Completion: September 1, 2024
• Study Completion: September 1, 2024
• Last Updated: May 21, 2025

Record last verified: 2025-05

Locations

TU (1)